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The hair follicle dermal sheath is essential for hair shedding and needs to communicate with the outer root sheath for normal hair growth cycles.

PRC1 influences skin stem cell development by both turning genes on and off, affecting hair growth and skin cell types.

The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

Finasteride works better for baldness in people with shorter gene repeats.

Baldness may lower the risk of testicular cancer.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Muscles and nerves that cause goosebumps also help control hair growth.

Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.

Hair loss patterns differ between males and females due to 5 master regulators and JAK-STAT signaling affects hair growth.

Blocking JAK-STAT5 signaling in mice leads to hair growth.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Sirolimus and propranolol may reduce abnormal cell growth and improve lymphatic malformations in children.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Birth control pills combined with bicalutamide are more effective at reducing excessive hair growth in women with PCOS than birth control pills alone.

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

Certain DNA variants can predict straight hair in Europeans but are not highly specific.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

Spermidine may help reduce hair loss and deserves further testing as a treatment.

The hemp extract significantly increased hair regrowth in both men and women without any side effects.

Some drugs can cause hair loss or increase hair growth, but these effects are usually reversible when the drug is stopped.

D-OCT shows increased blood vessel growth in response to tissue damage in Frontal Fibrosing Alopecia and is useful for diagnosis and monitoring.

New methods improve how we test hair growth treatments, but challenges like slow hair changes and high costs remain.

Early balding linked to higher heart disease risk.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Many treatments for hair loss show potential, but more testing is needed to confirm their effectiveness. Only minoxidil for women and minoxidil and finasteride for men are FDA approved.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Using nanostructured lipid carriers to deliver spironolactone could improve treatment for hair loss.

Laser treatment increases hair density and thickness safely in women with hair loss.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.