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Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

Treatment during development affects hormone balance and sexual behavior in male rats.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Thyroid receptor agonists may treat male pattern baldness without harmful side effects.

Polygonum multiflorum extract helps hair grow longer and fights the effects of hormones that cause hair loss.

Hsc70 protein may influence hair growth by responding to androgens.

The study created a new method to test drugs that affect hormone processing in skin.

The mouse models are effective for testing new hair loss treatments.

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

Blocking the prolactin receptor might help treat various diseases, but more research is needed.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

Glioblastoma cells can make androgens, which might help the tumor grow.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

Androgens may worsen COVID-19 and hair loss could indicate the disease's severity.

Removing part of the vitamin D receptor stops vitamin D from working properly.

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.