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Flutamide and finasteride reduced sex hormones in pregnant hyenas, but increased them in males.

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

The mouse models are effective for testing new hair loss treatments.

Androgens may worsen COVID-19 and hair loss could indicate the disease's severity.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Experts recommend using evidence-based methods to diagnose and treat hirsutism, focusing on symptoms and underlying causes.

The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Hirsutism is more linked to high androgen levels than acne or hair loss, and a mix of hormonal tests is best for diagnosis; certain treatments can reduce symptoms.

The conclusion is that managing androgen excess requires long-term treatment, including hormonal contraceptives and androgen blockers, with follow-up after six months.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

Androgens can both promote and prevent hair growth due to differences in gene expression in hair follicles.

Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

Antiandrogen drugs can reduce PSA levels in women with excess hair, suggesting PSA is a sign of male hormone activity in women.

MENT could be a better option than testosterone for male hormone therapy and birth control because it works well at lower doses and has fewer side effects on the prostate.

Testosterone therapy can help women with androgen deficiency by improving energy, sex drive, and bone health with few side effects.

A protein called ectodysplasin-A2 increases a hair growth inhibitor in balding cells, which could be a target for hair loss treatment.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.

Androgen therapy might help some women with low libido, but it has risks and should be used carefully.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Removing part of the vitamin D receptor stops vitamin D from working properly.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Using anabolic androgenic steroids can cause serious, lasting health problems in many parts of the body.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.

Anti-androgens are safe and effective for treating moderate to severe adult female acne.