research Is Prostate-Specific Antigen a Potential New Marker of Androgen Excess in Polycystic Ovary Syndrome?
Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.
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research Anti-Müllerian Hormone Gene Polymorphism Is Associated With Androgen Levels in Chinese Polycystic Ovary Syndrome Patients With Insulin Resistance
Certain gene variations are linked to higher male hormone levels in Chinese women with PCOS and insulin resistance.
research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia
research Graham Little–Piccardi–Lassueur Syndrome in a Patient with Androgen Insensitivity Syndrome
research The Effect of Curcumin on Metabolic Parameters and Androgen Level in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial
Curcumin improved some metabolic factors in women with PCOS but did not affect cholesterol, insulin, or testosterone levels.
research Evidence-Based Guidelines for Treating Androgenetic Alopecia in Men and Women
The document provides guidelines for effective and safe treatments for hair loss in men and women.
research The Effect of Sleep Extension on Metabolic and Androgen Parameters of Healthy Women with Habitual Short Sleep Duration: Pilot Study
Increasing sleep by 41 minutes daily for a month showed no significant changes in metabolism or hormone levels in healthy women.
research Cross-Interactions of BMP and WNT Signaling Pathways Attenuate Androgen Effect on Hair Follicle Stem Cell Differentiation
BMPs are important for hair growth and can counteract the negative effects of androgens on hair follicle stem cells.
research Investigation of Follicle Stimulating Effect of Medical Cosmetic Remedies on the Androgen Alopecia Model in Rats
The cream-mask and gel-mask with certain plant extracts improved hair growth in rats similar to a common hair growth treatment.
research Effects of Antiandrogen Therapy of Cyproterone Acetate on Androgen Effects on the Skin Including Androgenetic Alopecia in Menopausal Women: Case Report, 10 Years Follow-Up
Cyproterone acetate therapy improved hair loss and reduced testosterone levels in a menopausal woman.
research Author Correction: Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia
research Faculty Opinions Recommendation of Female Pattern Hair Loss and Androgen Excess: A Report from the Multidisciplinary Androgen Excess and PCOS Committee
research Vitamin D Level in Female Pattern Hair Loss with Normal Androgen Level
Lower vitamin D levels may contribute to female hair loss.
research The Roles of Hepatocyte Growth Factor Family Members in Androgen-Regulation of Human Hair Growth: A Comparison of the Expression of Hepatocyte Growth Factor Family Members, HGF and MSP, and Their Receptors, c-Met and RON, in Isolated Hair Follicles from Normal and Androgenetic Alopecia (Balding) Scalp
research A Study on CAG Repeat Polymorphisms of the Androgen Receptor in Korean Androgenetic Alopecia: Preliminary Report
research Hirsutography: Photographic Measurement of Linear Hair Growth in Hirsute Women During Comparison of Anti-Androgen Treatments
The photographic method accurately measures hair growth and both treatments effectively reduced hair growth in hirsute women.
research Androgens Activate Lipogenesis Through an AKT-Independent mTOR Pathway Stimulation and a Limitation of Autophagy in an Androgen-Sensitive Sebocyte Cell Line
Dihydrotestosterone (DHT) increases oil production in skin cells by activating mTOR, and mTOR inhibitors can reduce this effect.
research Progressive Effects of an Anti-Androgen on Sebaceous Secretion and Body Hair Growth in Hirsute Women
research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1
The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.
research The Evaluation of the Role of Androgens in Hirsutism and the Use of a New Anti-Androgen Cyproterone Acetate for Therapy
Cyproterone acetate combined with ethinyl estradiol significantly reduced hirsutism in women.
research The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen
Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.
research Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract
Shallot extract may help with hair growth and treating hair loss.
research Preponderance of Serum and Intra-Hepatic 5α-Dihydrotestosterone in Males with Hepatocellular Carcinoma Despite Low Circulating Androgen Levels
Men with liver cancer have higher levels of a specific testosterone byproduct in their liver and blood, despite overall lower male hormone levels.
research Structure of Human Steroid 5α-Reductase 2 with Anti-Androgen Drug Finasteride
The research helps understand how finasteride works and aids drug development.
research Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling
A specific RNA can help hair growth in baldness by boosting stem cell activity.
research In Silico Screening of DrugBank Compounds as Potential Inhibitors for Human Steroid 5α-Reductase 2 for Androgen-Related Diseases
The study conducted an in silico screening of 9,213 DrugBank compounds to find potential inhibitors for the enzyme Steroid 5α-reductase 2 (SRD5A2), which is associated with androgen-related diseases like alopecia. Eleven compounds showed better binding energy than testosterone, with mestranol, lorcaserin, phenindamine, and stiripentol interacting with key SRD5A2 residues. Stiripentol was highlighted as a promising candidate for drug repositioning due to its favorable interaction profile and mild side effects, forming a crucial hydrogen bond with E57. However, it did not interact with the R114 side chain, indicating the need for further in vivo trials to confirm its efficacy and safety for treating SRD5A2-related conditions.
research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
research Protease Nexin-1 Is Expressed in Human Dermal Papilla Cells and Is Affected by Androgen
Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.
research Estimation of Serum Aldosterone, Free Testosterone, and DHEA-S and Scalp Androgen and Aldosterone Receptors in Female Androgenetic Alopecia: Is the Mystery Solved?
High aldosterone and free testosterone levels link to female hair loss; testing aldosterone may predict hypertension risk.
research Summary of the Recommendations on Sexual Dysfunctions in Women
Experts recommend thorough medical, sexual, and psychosocial assessments for women's sexual dysfunctions, and suggest individualized treatment plans with regular check-ups. They also mention potential use of estrogen and androgen therapy, but with caution due to safety concerns.