Effects of Antiandrogen Therapy of Cyproterone Acetate on Androgen Effects on the Skin Including Androgenetic Alopecia in Menopausal Women: Case Report, 10 Years Follow-Up

    May 2022 in “ Endocrine Abstracts ”
    Dragan Tesic, Milena Mitrovic, Tijana Icin, Dragica Andric, Mirjana Tomic
    TLDR Cyproterone acetate therapy improved hair loss and reduced testosterone levels in a menopausal woman.
    This case report follows a menopausal woman experiencing symptoms of androgen excess, including female pattern hair loss (FPHL), over a 10-year period. Despite initial weight loss and reduced insulin levels, her alopecia and hirsutism persisted. The introduction of cyproterone acetate therapy led to a significant reduction in testosterone levels and clinical improvement in her alopecia, reducing it from Grade 3 to Grade 1. The report highlights the importance of normalizing testosterone levels to mitigate androgenization effects, such as alopecia and hirsutism, and suggests that reducing hyperinsulinemia alone may not be sufficient for these improvements.
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