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This case report from the University of Alabama describes a rare paradoxical effect where divalproex sodium was associated with increased agitation and hostility in a patient with schizoaffective disorder.

This study provides a detailed overview of 1,295 clinical trials related to alcohol dependence registered on ClinicalTrials.gov, highlighting that 59.15% of these trials have been completed, primarily as interventional studies, with most located in North America.

In this study, dry powder inhalers containing Cepharanthine were administered to rats with acute lung injury, significantly reducing pulmonary edema, hemorrhage, and inflammatory markers, suggesting its potential as an effective anti-inflammatory treatment when inhaled directly into the lungs.

This study identified new potential targets and indications for several marketed drugs using in silico profiling, suggesting opportunities for drug repositioning.

The researchers reported that a novel family of butyric acid prodrugs, including AN-9 and AN-10, showed potential for anticancer activity, hemoglobin expression induction, and hair follicle protection, with AN-9 in phase II trials.

This study found that Iraqi male bodybuilders abusing anabolic androgenic steroids experienced significant changes in sex hormones, liver and kidney function, and lipid profiles compared to non-AAS-using controls.

In this study, transdermal application of anabolic steroids demonstrated rapid and extended detectability in urine, suggesting potential implications for doping control considerations.

Anesthetizing walruses is difficult and risky due to their size and sudden health changes.

This abstract compiles a comprehensive list of drug reactions and interactions across various pharmaceuticals but reports no specific research findings.

This study found that a specific amino-pyridine compound showed potent androgen receptor antagonist activity, stimulating hair growth in mice and reducing sebum production in a hamster model.

This study reported that chronic use of performance-enhancing drugs significantly altered users' personalities and physical attributes, raising concerns about whether the perceived benefits outweigh the costs.

This study found that thalamic GABAA receptor α4 subunit levels increased after prolonged ethanol exposure and were regulated by phosphorylation and neuroactive steroids following acute high-dose ethanol administration.

In this study, researchers synthesized the fictional compound 1-hydroxyindole and discovered its potential medical applications, including anti-aging properties, itch relief for atopic dermatitis, and as a stronger treatment for dementia compared to cilostazol. Additionally, they found that 1-methoxyindole derivatives function as anticancer agents in diets.

This study introduced a new spectrofluorometric method using a synthesized organic fluorophore to effectively analyze darolutamide and thalidomide in pharmaceutical preparations and biofluids.

This study found that manipulating neuroactive steroids during early development stages in male rats influences alcohol-induced locomotor sensitivity, suggesting their role in addiction vulnerability.

This study found that the antiseizure activity of midazolam primarily occurs through synaptic GABA-A receptors, with no significant involvement of endogenous neurosteroids or extrasynaptic receptors.

This review discusses various drugs and their uses across multiple therapeutic categories but reports no new clinical results.

In this study, thalamic GABAA receptor α4 subunit levels were regulated after acute and chronic ethanol exposure, with temporal expression changes affected by phosphorylation state and neuroactive steroids.

This study found that dual ASM therapies involving valproic acid were associated with poorer tolerability and specific adverse events, with cognitive side effects occurring prominently across all examined combinations.

This study developed the CATNIP computational model, which uses biological and chemical information to successfully identify drug repurposing opportunities for various conditions, including Parkinson’s disease and Type 2 Diabetes.

This study identified several drugs that may be potential candidates for repurposing as anti-hyperhidrosis treatments, based on their association with hypohidrosis or anhidrosis in the FDA Adverse Event Reporting System.

This review focuses on neuroactive steroids' influence on GABA-ergic signaling and discusses challenges in developing them for various therapeutic uses, citing recent excitement from FDA approval of allopregnanolone for postpartum depression but reporting no new results.

AI-09 is safe, effective, and reduces wrinkles for up to 6 months.

In this report, an 18-year-old female with trichotillomania was successfully treated using the glutamate modulator n-acetylcysteine.

This study demonstrated that the glycolytic inhibitor 2-deoxy-D-glucose enhances antiseizure effects by potentiating extrasynaptic tonic GABAergic inhibition through neurosteroidogenesis in hippocampal slices.

This study reports that a 15-year-old with trichotillomania showed improvement with aripiprazole treatment, though no consensus on treatment exists in the literature.

This case report highlights the potential for Kratom misuse leading to addiction and significant health risks, indicating a need for more detailed human studies on its effects and management strategies.

This study observed that overexpressing TSPO in the hippocampal dentate gyrus of mice led to significant anxiolytic and antidepressant-like effects, potentially mediated by increased allopregnanolone synthesis.

This study found that subcutaneous injections of guanethidine or 6-hydroxydopamine induced premature hair growth in mice, suggesting a role for sympathetic nerves in hair growth control.

This study found that ethanol-induced deficits in motor coordination in rats are not mediated by elevated neuroactive steroid biosynthesis.