Pharmacovigilance-Based Drug Repurposing: Searching for Putative Drugs With Hypohidrosis or Anhidrosis Adverse Events for Use Against Hyperhidrosis

This study investigates repurposing drugs that cause hypohidrosis or anhidrosis to treat hyperhidrosis by analyzing FAERS data from 2004 to 2021. Researchers identified 540 reports involving 192 drugs, with 39 showing significant signals. Key candidates for hyperhidrosis treatment include glycopyrronium, solifenacin, oxybutynin, and botulinum toxin type A, while others like topiramate and zonisamide need further research. The study underscores the potential of pharmacovigilance in finding new therapeutic uses for existing drugs, despite limitations like reporting biases and the need for more clinical trials.