A Review of the Characteristics of Clinical Trials and Potential Medications for Alcohol Dependence: Data Analysis from ClinicalTrials.gov

June 2023 in “ Medicina ”

Fahad S. Alshehri

TLDR No medications for alcohol dependence have been approved for marketing yet.

This systematic review analyzed 1,295 clinical trials on alcohol dependence from ClinicalTrials.gov, with 766 completed and 230 recruiting. Most trials were interventional (88.41%) and conducted in North America (67.64%). The review highlights the need for more effective pharmacological treatments, as none of the trials had been approved for marketing. Naltrexone, Topiramate, and Acamprosate were the most studied drugs, with Naltrexone being the most frequently researched. The study emphasizes the need for more resources and comprehensive studies to address alcohol dependence, a significant global health issue.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Dutasteride in Androgenetic Alopecia: An Update

27 citations , March 2017 in “Current Clinical Pharmacology”

Dutasteride is becoming a popular hair loss treatment, proving more effective than finasteride with similar side effects.

research Current Pharmacological Treatment for Male LUTS Due to BPH: Dutasteride or Finasteride?

21 citations , October 2015 in “Current Drug Targets”

Both dutasteride and finasteride improve urinary symptoms, but dutasteride may be better at reducing the risk of prostate surgery and sudden inability to urinate.

research Dutasteride Reduces Alcohol’s Sedative Effects in Men in a Human Laboratory Setting and Reduces Drinking in the Natural Environment

32 citations , February 2014 in “Psychopharmacology”

Dutasteride makes alcohol less sedating and may lead to less drinking in men.