8 citations
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October 2010 in “Scandinavian Journal of Clinical & Laboratory Investigation” This study found that normal ALT levels in women of reproductive age are linked with metabolic and androgenic abnormalities, suggesting ALT could be used beyond liver disease diagnoses.
December 2022 in “Cumhuriyet medical journal” This study observed that women with PCOS and no hyperandrogenism (group 3) had similar metabolic issues to those with classic PCOS, while those with no menstrual dysfunction (group 2) had milder issues related to lipid and insulin resistance.
53 citations
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December 2012 in “Revista da Sociedade Brasileira de Medicina Tropical” In this study, liver transaminase levels and various symptoms persisted in some adult dengue patients even two months after diagnosis.
9 citations
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April 2023 in “World Journal of Clinical Cases” Test liver enzymes and triglycerides every 5-6 months, and cholesterol levels in the first two months for acne patients on isotretinoin.
August 2025 in “Journal of Medical and Life Science” This case-control study in Missan Province, Iraq, found that married women with PCOS had higher rates of obesity and menstrual irregularities, along with elevated testosterone, LH, and insulin levels, compared to healthy controls, highlighting significant hormonal and metabolic complications.
October 2023 in “Journal of pharmaceutical investigation” In this study, researchers found that among healthy Korean males, the clearance of finasteride was about 34% lower in individuals with the CYP3A5*3 homozygous allele compared to other genotypes, suggesting dosage adjustments may be necessary considering CYP3A5 and ALT levels to avoid adverse effects.
20 citations
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June 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found that long-term dutasteride therapy in men with benign prostatic hyperplasia worsened erectile dysfunction, reduced testosterone levels, and increased blood glucose and lipid profile, indicating negative metabolic impacts.
February 2026 in “International Journal of Advanced Biochemistry Research” This study reports that dogs with dermatoses linked to hypothyroidism displayed a significant incidence of specific haematological and biochemical alterations, such as elevated cholesterol and triglyceride levels and reduced thyroid hormones, compared to healthy dogs, with Labrador Retrievers showing the highest breed predisposition.
June 2016 in “The Egyptian Journal of Forensic Sciences and Applied Toxicology” In this study, long-term occupational exposure to benzene in fueling workers was associated with increased skin diseases, altered blood cell counts, and elevated liver enzyme levels compared to overseers.
September 2023 in “Translational medicine reports” This case study reported that an 18-year-old woman ingested a large amount of topical minoxidil, leading to symptoms like low blood pressure, increased heart rate, and elevated liver enzymes, but recovered fully after treatment. Minoxidil toxicity may rarely cause abnormal liver enzyme levels.
2 citations
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July 2019 in “PLOS ONE” This study found that the CYP3A4 rs4646437 genotype was significantly associated with ALT elevation in Japanese patients undergoing asunaprevir plus daclatasvir therapy for chronic HCV infection, suggesting genotyping may help in monitoring patients safely.
29 citations
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July 2012 in “Fertility and Sterility” This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
15 citations
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May 2022 in “Fermentation” This study found that fermented camel milk containing 50% pumpkin seed milk significantly improved oxidative stress markers in rats and enhanced sensory and physicochemical properties compared to untreated groups.
2 citations
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August 2020 in “Journal of Nutritional Science and Vitaminology” In this study, yellow Chinese chive extract was observed to protect against acetaminophen-induced liver toxicity in mice by enhancing antioxidant pathways and reducing liver injury markers.
March 2017 in “Iraqi Journal of Pharmaceutical Sciences” This study found that Iraqi male bodybuilders abusing anabolic androgenic steroids experienced significant changes in sex hormones, liver and kidney function, and lipid profiles compared to non-AAS-using controls.
20 citations
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December 2016 in “Neurodegenerative disease management” This study found that teriflunomide, an oral medication taken once daily, significantly slowed disability progression in patients with relapsing multiple sclerosis, supported by positive results in two Phase III trials and supplemented by various analyses including long-term studies and patient-reported outcomes.
3 citations
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January 2013 in “Egyptian Liver Journal” In this study, researchers found a significant prevalence of nonalcoholic fatty liver disease in Egyptian women with polycystic ovary syndrome, with insulin resistance being a key predictive factor.
1 citations
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January 2014 in “Assiut Veterinary Medical Journal/Maǧallaẗ Asyūṭ al-ṭibiyyaẗ al-baytariyyaẗ” This study in Aswan governorate reported that emaciated cattle showed decreased blood cell counts and serum minerals, as well as elevated liver enzymes, possibly associated with parasitic infections.
January 2026 in “E3S Web of Conferences” This study found that silver nanoparticles synthesized using Mitracarpus scaber extract showed potential hepatoprotective and anti-hyperplastic effects in rats, suggesting novel therapeutic strategies for managing liver injury and benign prostatic hyperplasia.
55 citations
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August 2012 in “Resources and Environment” This study found that landfill leachates from Olusosun and Aba-Eku in Nigeria can cause liver and kidney dysfunction in Wistar rats, potentially posing a health risk through chemical exposure.
January 2026 in “Springer Link (Chiba Institute of Technology)” In this study, researchers synthesized silver nanoparticles using an extract from Mitracarpus scaber and found them to have significant hepatoprotective and anti-hyperplastic effects in rats, suggesting potential for treating liver injury and benign prostatic hyperplasia.
December 2023 in “Journal of Science Innovations and Nature of Earth” In this animal study on albino rats, researchers reported that Tribulus terrestris extract significantly reduced liver damage markers caused by cyproterone acetate, suggesting a protective effect on liver function against this drug's hepatotoxicity.
This study reported that severe hypothyroidism in two pediatric patients was associated with transient liver and kidney dysfunction, which resolved after beginning levothyroxine treatment.
June 2013 in “Ciencia e Investigación” In this study, oral administration of modified aloe gel significantly reduced liver enzymes AST and ALT and led to hair regrowth in carbon tetrachloride-treated albino mice after 33 days.
6 citations
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July 2013 in “Archives of Plastic Surgery” This article explains that proliferating trichilemmal tumors, originating in the hair follicle, can exhibit low-grade malignant potential, and recommends wide excision to minimize recurrence risk, but reports no new clinical findings.
36 citations
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January 1993 in “Gut” In this study, a high daily dose of interferon alfa-2b administered initially six times a week for two weeks followed by thrice weekly for 12 weeks was most effective in sustaining normal ALT values in patients.
April 2022 in “SDÜ Tıp Fakültesi Dergisi” In this study, sodium benzoate at the No Adverse Effect Level dose adversely affected kidney and liver function and increased oxidative stress and genotoxicity in prepubertal rats.
17 citations
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January 1993 in “Journal of Gastroenterology and Hepatology” This study found that recombinant IFN α-2b injections in patients with acute post-transfusion hepatitis C can suppress viral RNA and lead to normalization of serum ALT, though long-term prevention of chronicity remains unclear.
August 2024 in “Indian Journal of Entomology” This study found that rabbits with mange showed significant declines in haemoglobin, PCV, and RBC count, alongside increased TLC and liver enzyme levels. Following treatment with ivermectin and proper management, recovery from the disease was observed.
In this study, bicalutamide at low doses was not linked to significant liver enzyme changes compared to other androgen-blocking treatments in transfeminine adolescents and young adults, suggesting its safety with careful monitoring for this population over one year.