Effect of Modified Aloe Vera Gel in the Treatment of Hepatotoxicity and Alopecia Induced by CCL and DMSO in Mice

    June 2013 in “ Ciencia e Investigación ”
    Félix Saavedra, Haydée Zúñiga, José A. Apesteguía, Henry Ostos
    From the encyclopedia
    Aloe vera →
    DMSO →
    Studysummary In this study, oral administration of modified aloe gel significantly reduced liver enzymes AST and ALT and led to hair regrowth in carbon tetrachloride-treated albino mice after 33 days. Our plain-language summary of this paper — not a Tressless recommendation.
    The study aimed to evaluate the reversibility of hair loss and liver enzyme variations in albino mice induced by oral administration of carbon tetrachloride and dimethyl sulfoxide (DMSO). The mice were treated with modified Aloe vera gel (GSM) at a daily dose of 8 mL/kg. Results showed a significant and progressive decrease in liver enzymes AST and ALT over 33 days, with no changes in proteins and phosphatases. Triglyceride levels significantly decreased in the first week. Mice treated with GSM also showed hair regrowth on the chest and snout by day 33. Control groups showed no significant changes in the studied indicators.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results