Investigation of the Effects of Food Additive Sodium Benzoate on Oxidative Stress and Genotoxicity

    April 2022 in “ SDÜ Tıp Fakültesi Dergisi ”
    İlter İlhan, Duygu Kumbul Doğuç, Muhammet Yusuf Tepebaşı, Okan Sancer, Halil İbrahim Büyükbayram
    TLDR Sodium benzoate at higher doses can harm kidney and liver functions and cause oxidative stress and DNA damage.
    The study investigated the effects of sodium benzoate on oxidative stress and genotoxicity in 42 prepubertal male rats. The rats were divided into three groups: control, Acceptable Daily Intake (ADI) dose, and No Adverse Effect Level (NOAEL) dose of sodium benzoate. After 6 weeks, the NOAEL group showed increased levels of ALT, creatinine, total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidative stress index (OSI), while total antioxidant status (TAS) was decreased, indicating impaired kidney and liver functions. DNA damage was also observed in the NOAEL group. The study concluded that while the ADI dose had no adverse effects, the NOAEL dose could lead to oxidative stress and genotoxicity, suggesting potential health risks associated with sodium benzoate consumption.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results