47 citations
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July 2004 in “Journal of Dermatological Science” In this study, decreased expression of BMP2 and ephrin A3 and increased NT-4 gene expression were observed in dermal papilla cells from androgenic alopecia-affected skin, suggesting potential roles in hair growth regulation.
88 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This article reviews recent advancements in understanding and treating androgenetic alopecia, focusing on new genetic insights, stem cell roles, and diagnostic tools, without reporting new clinical results.
January 2014 in “Jaypee Brothers Medical Publishers (P) Ltd. eBooks” This article discusses androgenetic alopecia, including its prevalence, different patterns in men and women, and variations among races, without providing new clinical findings.
42 citations
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April 2009 in “Human Genetics” This study suggests that the AGA risk haplotype in Europeans was driven to high frequency by positive selection, likely associated with a variant in the EDA2R gene.
1 citations
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March 2021 in “Dermatological reviews” This review discusses recent advances in understanding the pathophysiology and molecular mechanisms of androgenetic alopecia in males, females, and children, but reports no new clinical results.
13 citations
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June 2015 in “International Journal of Dermatology” In this study, non-obese females with early-onset androgenetic alopecia showed higher total cholesterol, LDL cholesterol, triglycerides, and atherogenic index, and lower HDL cholesterol compared to controls, suggesting an association with adverse cardiovascular risk factors.
May 2022 in “Dermatology practical & conceptual” This study developed new graded visual scales integrating macroscopic and trichoscopic images for assessing the severity of androgenetic alopecia in men and women, potentially aiding in more objective disease evaluation.
March 2011 in “European Urology Supplements” Blood tests for tumor cells could improve prostate cancer diagnosis and treatment; hair loss severity linked to a gene affecting prostate conditions.
January 2013 in “Anthropology” This article discusses the challenges in accurately estimating an individual's age in forensic and anthropological contexts and reports no definitive method; the authors highlight the need for acceptable error margins.
January 2014 in “生命科学(ISSN1934-7391)” A certain gene variation can affect protein production and is linked to male pattern baldness.
May 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review explores the complex pathophysiology of androgenetic alopecia, highlighting genetic factors, androgen metabolism, and emerging therapies such as platelet-rich plasma and low-level laser therapy, but notes that no ultimate cure exists and treatments focus on slowing progression and promoting hair growth.
January 2019 in “Journal of the Egyptian Women's Dermatologic Society (Print)” This study found that patients with androgenetic alopecia exhibited higher levels of cardiovascular risk markers, with hs-CRP identified as a significant independent predictor of cardiovascular disease risk.
8 citations
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December 2017 in “Skin appendage disorders” This study observed that the genes WNT7A, CASP7, and TNF were overexpressed in early stages of androgenetic alopecia, suggesting involvement of the WNT pathway, apoptosis, and inflammation in the disorder's development.
July 2025 in “Journal of Investigative Dermatology” In this study, higher expression of PEDF was observed in hair follicles from balding regions in AGA patients, suggesting that targeting PEDF could be a promising approach for treating androgenetic alopecia.
32 citations
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February 2017 in “Human Reproduction” This study found that women with PCOS were more likely to have longer anogenital distances, indicating possible intrauterine origins linked to prenatal androgen exposure.
57 citations
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May 2016 in “Journal of Dermatological Treatment” This analysis suggests that platelet-rich plasma therapy may be promising for treating androgenetic alopecia, but further controlled trials with standardized measures are needed to confirm its efficacy.
June 2026 in “Expert Opinion on Pharmacotherapy” This article reviews emerging therapies for androgenetic alopecia, highlighting advances like androgen-receptor antagonists and improved minoxidil delivery that aim to enhance treatment efficacy and safety.
1 citations
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August 2022 in “Journal of Drugs in Dermatology” This study found that the efficacy of platelet-rich plasma in treating androgenetic alopecia is higher with increased frequency of sessions, chemically-activated PRP, double centrifugation, and whole-head application, among younger and female patients.
Early balding may be a sign of future prostate problems.
April 2023 in “Journal of Investigative Dermatology” In this study, several photobiomodulation devices showed statistically significant improvement in hair growth for patients with androgenetic alopecia, with varying efficacy between devices and genders.
66 citations
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February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.
8 citations
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June 2019 in “Scientific Reports” This study found that the retinoid receptor and PPAR pathway are involved in hair follicle miniaturization in androgenetic alopecia, alongside androgen receptors.
16 citations
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September 2016 in “Neuropharmacology” This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.
3 citations
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January 2008 in “Endocrine journal” In this case report, the authors describe a partial androgen insensitivity syndrome patient with a novel AR gene mutation, highlighting challenges in gender assignment decisions for infants with partial AIS.
April 2019 in “Journal of the Endocrine Society” This case report documents successful virilization, including penile length increase, in a boy with partial androgen insensitivity syndrome using high-dose testosterone combined with anastrozole.
43 citations
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May 1999 in “Journal of Biological Chemistry” This study found that full-length Agouti protein modulates melanocortin receptor signaling through a dual mechanism involving competitive antagonism and receptor down-regulation, whereas the carboxyl-terminal fragment acts solely as a competitive antagonist.
2 citations
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March 2024 in “JAAD Case Reports” In this study, platelet-rich plasma treatments over three months were reported to improve hair growth in individuals with androgenetic alopecia, although objectively measuring its efficacy remains challenging.
7 citations
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January 2013 in “Egyptian Journal of Dermatology and Venereology” This study found that male patients with androgenetic alopecia had significantly higher aldosterone levels and blood pressure compared to controls, suggesting a possible link between AGA and hypertension.
March 2024 in “Healthcare” In this study, women with androgenetic alopecia underwent stem cell treatment, which led to significant improvements in sexual arousal and satisfaction, psychological health, and environmental quality of life, but not in physical health or social relationships after six months.
March 2012 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Hair loss can be an early sign of prostate enlargement.