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Losing 5-10% body weight can improve PCOS symptoms, letrozole is better than clomiphene for fertility, and managing weight and blood sugar is important to reduce pregnancy complications.

Local skin glucocorticoid production is crucial for healthy skin, and its disruption can lead to skin diseases.

The document concludes that Rabson-Mendenhall syndrome requires novel treatments for insulin resistance and emphasizes the importance of dental care in affected patients.

The document suggests that blocking sweat glands with antiperspirants might allow skin-generated hormones to be absorbed, possibly increasing breast and prostate cancer risk.

Flutamide works better than finasteride for hirsutism, and combining both is slightly better but not much.

COVID-19 may harm male fertility and damage the reproductive system.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

Surgery to lower high testosterone in postmenopausal women with certain ovarian tumors doesn't significantly affect their metabolism.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

The document concludes that more research is needed to fully understand the causes of PCOS.

Chronic scalp pain in trichodynia involves both body-wide and localized increased pain sensitivity.

Metformin helps manage diabetes, PCOS, and weight in kids but needs more research for long-term safety.

The document suggests various treatments for PCOS, including medication for menstrual issues, insulin resistance, and excess hair, as well as fertility treatments, while highlighting the need for personalized care and lifestyle changes.

Antiandrogen drugs can reduce PSA levels in women with excess hair, suggesting PSA is a sign of male hormone activity in women.

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

Laser hair removal is effective for dark hair but needs improvement for nonpigmented or fine hairs.

Women with low SHBG levels and a high 3a-diol G to SHBG ratio are likely to experience female pattern baldness, possibly due to a slight excess of androgens affecting sensitive hair bulbs.

Menopausal acne is treated with medications and lifestyle changes, but careful choice is needed due to side effects.

New treatments for excessive hair growth in women include insulin modulators and enzyme inhibitors.

Sebaceous glands in our skin, developing during pregnancy and active in puberty, produce sebum for skin lubrication, temperature control, and fighting germs, also help in hormone regulation, and their dysfunction can cause conditions like acne and hair loss.

Melatonin stimulates the skin components of ram's scrotum during their non-breeding season.

Proper diet management is crucial for phenylketonuria patients to avoid severe health issues.

Most hirsutism patients had idiopathic hirsutism or PCOS, with hormonal imbalances and signs like acne and irregular periods.

The oral contraceptive ethinylestradiol/chlormadinone acetate is effective in reducing acne and improving other skin conditions related to high androgen levels.

A postmenopausal woman's hirsutism and high testosterone levels improved after surgery for an ovarian tumor not seen on ultrasound.

The Androgen Receptor could be a target for treating diseases like cancer, but more research is needed to confirm the effectiveness of potential treatments.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.