Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study observed that women with PCOS exhibited higher levels of triglycerides, fasting insulin, HOMA-IR, total testosterone, DHEAS, and LH/FSH ratio, and lower HDL cholesterol compared to healthy controls, with these markers varying across different PCOS phenotypes.

The researchers reported creating a Human Hair Atlas that maps over 1200 molecular species in hair, revealing up to 50% variation in metabolite and lipid levels along the hair's length, and identified 122 exposome-related compounds from personal care products.

This review discusses coordinated management strategies for polycystic ovary syndrome across various levels of care but reports no new clinical results.

This study developed a model using homogenization-based framework to quantify solvent and solute flow across Janus membranes, aiming to better understand interface phenomena like osmosis and phoresis by examining micro- and macro-scale behaviors.

This study found variation in erythema induction across skin types, suggesting different SSR dose responses and highlighting a potential model for tailoring anti-inflammatory treatments.

This study suggests that measuring hair DHEA and testosterone can reliably reflect long-term average hormone levels in women, overcoming daily and menstrual fluctuations seen in salivary hormone assessments.

This study found that silica nanoparticles penetrate the outer stratum corneum of human skin, with surface hydrophobization potentially enhancing this penetration.

This study suggests that the combination of bendamustine and rituximab is at least as effective and possibly offers a better therapeutic index than other standard regimens as first-line treatment for certain lymphoma patients.

This pilot study found that hair metabolome analysis may help differentiate pregnancy complications from healthy pregnancies by revealing significant metabolite differences between trimesters.

This study found that global PCOS prevalence in adolescents is 6.3% under new 2023 guideline criteria, compared to 9.8% using Rotterdam criteria; excluding PCOM may prevent over-diagnosis, while recognizing irregular cycles or hyperandrogenism helps avoid under-diagnosis by identifying at-risk individuals for further monitoring.

This study extended a skin diffusion model to include a porous pathway, effectively explaining the permeability of both polar and lipophilic solutes through the stratum corneum.

This study, using multimodal profiling in mice, found that various tissues contain unique γδ T cell subsets adapted to their environment, revealing their functional diversity, lineage relationships, and similarities to CD8+ tissue-resident memory T cells.

In this study, the researchers observed that the transdermal permeation mechanisms of diclofenac salts differ based on counterions, with varying pathways and routes for passive and iontophoretic transport.

This study found that hydrophobic lipid-coated silica nanoparticles penetrated deeper into human stratum corneum compared to their hydrophilic counterparts, highlighting the influence of surface polarity on skin penetration.

This case report describes a 12-year-old boy with congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis, highlighting the severe complications and the necessity for early intervention.

This article discusses the need for a globally standardized protocol for epidemiologic studies of polycystic ovary syndrome to improve study comparability and public health policy.

In this study, researchers found that a composition containing mannose-6-phosphate significantly reduced the total skin pore area by 24% in women after 56 days and by 30.2% in men after 7 days, suggesting its effectiveness in improving pore appearance by targeting dermal and epidermal modifications.

This study highlights the crucial role of medicinal plants in treating major public health illnesses and stresses the importance of their domestication and cultivation to prevent depletion due to human activities and unregulated collection.

This study discovered a conserved "fiber-like-motif" of melanosomes aligned in hair across various mammalian species, shedding light on the internal structure that influences hair's thermal and mechanical properties.

GLP-1RA medications may increase the risk of hair loss, especially in non-diabetic people.

This review synthesizes both traditional and emerging molecular mechanisms of tissue remodeling across different organs, aiming to establish a theoretical basis for precision interventions in pathological conditions, according to the authors.

This narrative review suggests that intermediate filaments like vimentin and keratin play a significant role in various stages of viral infection, presenting potential antiviral intervention targets.

This narrative review summarizes evidence on NAD⁺ biosynthesis and turnover, highlighting that while NAD⁺ precursors like NR and NMN consistently boost NAD⁺ levels in preclinical and human studies, clinical outcome results remain varied, indicating a need for more standardized human trials.

PLGA-based microneedles show promise for painless, long-term drug delivery but need design and safety improvements.

This analysis concluded that mesenchymal stem cell-derived exosome therapy may offer a promising and safe approach for hair restoration, especially in androgenetic alopecia, despite limitations in study consistency and size.

This study found that arginine vasotocin is evolutionarily conserved across diverse taxa and may play roles in neuroendocrine, immune, and stress signaling, with potential antimicrobial applications.

This study identified distinct immune differences in patients with alopecia areata, particularly those with atopic backgrounds, and highlighted the OX40 axis as a potential therapeutic target for the condition.

This study found that a nutritional intervention in dogs led to changes in skin microbiome and immune-related gene expression, with reduced levels of certain fungal pathogens and a potential alleviation of atopic dermatitis symptoms.

This study demonstrated that LGR5 is a marker of hair follicle stem cells across species using a transgenic pig model and noted similarities and differences in expression patterns compared to humans.