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This study observed that injecting mice with α-MSH resulted in black hair regrowth in shaved and plucked areas, suggesting a potential link to the agent darkening hair in animals with a specific pituitary tumor.

This study explored the potential of silk fibroin methacrylate hydrogel microneedles to deliver α-MSH directly to the epidermis in vitiligo patients, enhancing melanocyte protection and melanosome transfer, potentially offering a new treatment avenue for this challenging condition.

ACTH promotes hair growth in mink, but α-MSH does not.

This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.

In this study, researchers found that exosomes derived from Pinctada martensii mucus can effectively inhibit melanin production in melanoma cells and zebrafish without adverse effects, potentially offering a promising therapeutic strategy for treating pigmentary disorders by modulating the NF-κB signaling pathway.

This study found that, despite confirming MC1R expression and functional cAMP signalling, α-MSH treatment did not alleviate UVA-induced stress in adult dermal fibroblasts, suggesting that α-MSH-MC1R may not directly protect against UVA-induced photoaging in these cells.

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

This review discusses the roles of the Agouti and Agouti-related proteins in pigmentation and energy regulation and reports no new experimental findings.

This article discusses the potential role of a local skin POMC system in the murine hair cycle and cutaneous stress responses, with no new results presented.

This study suggests that αMSH may play a regulatory role in human dermal papilla cells, potentially influencing immune and inflammatory responses in hair follicles, which could contribute to inflammatory alopecia.

In this study, α-MSH and cyclic AMP were found to stimulate melanogenesis in hair follicle cultures, while cyclic GMP and melatonin inhibited melanin production but not tyrosinase activity.

This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.

Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.

This review discusses how the brain can influence skin biology, suggesting a link between psychological factors and skin health, but it reports no new scientific findings.

This study found that α-MSH acts as a modulator of inflammatory and fibrogenic responses in human fibroblastic skin cells, indicating potential therapeutic options for fibrotic skin disorders and inflammatory diseases of the hair follicle.

This study found that α-MSH administration before skin wounding in adult mice reduced inflammation and scar area, suggesting a potential pathway to more regenerative healing.

This study found that glycine treatment inhibited melanogenesis in B16F0 melanoma cells and reduced melanin content in C57BL/6J mice by down-regulating tyrosinase protein levels.

This article discusses less commonly used and experimental treatments for vitiligo, focusing on therapies other than psoralen, but does not report new clinical results.

This article reviews the diverse regulatory roles of alpha-melanocyte-stimulating hormone in skin biology, highlighting its potential involvement in maintaining tissue homeostasis and protecting against inflammation-induced DNA damage but reports no new clinical findings.

This study found that α-melanocyte-stimulating hormone increased melanin production in hair follicles of moulting Siberian hamsters, whereas [8-arginine]-vasotocin inhibited melanin production without affecting tyrosinase activity.

This study by Pérez-Oliva et al. explored how Mahogunin Ring Finger-1 (MGRN1) affects melanocortin-1 receptor (MC1R) signaling, suggesting that MGRN1 competitively inhibits Gαs binding to MC1R, influencing pigment production.

This study found that human hair follicles can function like a peripheral hypothalamic-pituitary-adrenal axis, synthesizing cortisol in response to corticotropin-releasing hormone and adrenocorticotropic hormone stimulation.

This study reported that in men with androgenic alopecia, a distinct subclinical hyperpigmentation pattern was observed in the scalp, associated with baldness severity and possibly linked to local melanin production by pilosebaceous units.

This review discusses new insights into the pathogenesis of alopecia areata related to perifollicular immune and endocrine factors and potential new treatments, but it reports no clinical results.

This study found that α-MSH may suppress IFN-γ-driven upregulation of ICAM-1 in human dermal fibroblasts, suggesting potential roles for melanocortins in inflammatory skin disorders beyond collagen synthesis effects.

This study found that α-melanocyte-stimulating hormone may modulate inflammation in skin connective tissue by inhibiting proinflammatory effects in fibroblasts.

In this study, rapamycin was found to increase hair follicle pigmentation and prolong anagen duration in cultured human scalp hair follicles, suggesting it could be explored as an anti-greying agent.

This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.