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240-270 / 1000+ resultsresearch Caffeic Acid N-[3,5-Bis(Trifluoromethyl)Phenyl] Amide as a Non-Steroidal Inhibitor for Steroid 5α-Reductase Type 1 Using a Human Keratinocyte Cell-Based Assay and Molecular Dynamics
![5α-Reductase Inhibitors: Evaluation of Their Potential Confounding Effect on GC-C-IRMS Doping Analysis](/images/research/efb14eed-44f2-4aed-9d46-d7984ab4e96d/small/12043.jpg)
research 5α-Reductase Inhibitors: Evaluation of Their Potential Confounding Effect on GC-C-IRMS Doping Analysis
5α-reductase inhibitors can interfere with doping tests by masking banned substances.
![Dihydrotestosterone Stimulates 5α-Reductase Activity in Pubic Skin Fibroblasts](/images/research/ccfb56ab-33f2-4160-90a2-af617b0b19cb/small/28335.jpg)
research Dihydrotestosterone Stimulates 5α-Reductase Activity in Pubic Skin Fibroblasts
Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.
![5α-Reductase Inhibitors: A New Hope in Dermatology?](/images/research/bfed771c-e0c5-4df5-9e8f-17fe07ea1b59/small/34427.jpg)
research 5α-Reductase Inhibitors: A New Hope in Dermatology?
Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.
![5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis](/images/research/b319bbc1-b6be-464d-a316-83e9a4258dde/small/18771.jpg)
research 5α-Reductase Inhibitors Alter Steroid Metabolism and May Contribute to Insulin Resistance, Diabetes, Metabolic Syndrome, and Vascular Disease: A Medical Hypothesis
Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.
![5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder](/images/research/672039ef-07ae-4ad2-8c92-db231174611f/small/28646.jpg)
research 5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.
![5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia](/images/research/19838382-8417-45bb-b18c-c6562d042c31/small/2347.jpg)
research 5α-Reductase Inhibitors in the Treatment of Androgenetic Alopecia
Finasteride improves hair growth in men with androgenetic alopecia.
![5α-Reductase Inhibitors: Chemical and Clinical Models](/images/research/d1ad5b13-8113-4f8b-9d71-15859aa1f6fd/small/20519.jpg)
research 5α-Reductase Inhibitors: Chemical and Clinical Models
Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.
![In Vivo Time-Dependent Inhibition of Human Steroid 5α-Reductase by Finasteride](/images/research/36c05472-2dc1-4fa2-a4ff-51eab03e4d6e/small/2093.jpg)
research In Vivo Time-Dependent Inhibition of Human Steroid 5α-Reductase by Finasteride
Finasteride poorly inhibits type 1 5AR, affecting its effectiveness.
![5α-Reductase Inhibitors Increase Acute Coronary Syndrome Risk in Patients with Benign Prostate Hyperplasia](/images/research/a0bef807-788e-45f5-8fe5-95d7700fc8d0/small/14188.jpg)
research 5α-Reductase Inhibitors Increase Acute Coronary Syndrome Risk in Patients with Benign Prostate Hyperplasia
Taking both finasteride and dutasteride for prostate issues may raise the risk of heart problems.
research 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine
A plant extract was found to effectively block an enzyme related to male hormone-related diseases.
![Microalgae, Tetraselmis Tetrathele Has Alopecia Prevention and Scalp Improvement](/images/research/d9035cc8-b5ea-4fa5-ace8-fcad3e247aca/small/27267.jpg)
research Microalgae, Tetraselmis Tetrathele Has Alopecia Prevention and Scalp Improvement
Tetrathelmis tetrathele extract may help prevent hair loss and improve scalp health.
![Dermatology of Androgen-Related Disorders](/images/research/8579b79f-a29a-4f74-b43c-d8a8e4b8ae4a/small/15226.jpg)
research Dermatology of Androgen-Related Disorders
Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.
![Idiopathic Hirsutism: Androgen Role and Treatment Options](/images/research/159ccb8a-57b1-45a8-9145-a89f0d448056/small/20493.jpg)
research Idiopathic Hirsutism: Androgen Role and Treatment Options
The document concludes that more research is needed to understand excessive hair growth in women with normal hormone levels and regular ovulation.
![Hormone Therapy in Acne](/images/research/405d7689-56d3-40df-b1fc-648dc8ac95ef/small/25957.jpg)
research Hormone Therapy in Acne
Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.
![Clinical Trial and In Vitro Study Investigating Topical Application of Zataria Multiflora Boiss. and Matricaria Chamomilla Extracts for Androgenetic Alopecia](/images/research/a7e55cd1-0e91-49a0-bb34-95aaacaa1dc3/small/3969.jpg)
research Clinical Trial and In Vitro Study Investigating Topical Application of Zataria Multiflora Boiss. and Matricaria Chamomilla Extracts for Androgenetic Alopecia
Extracts improve hair growth in alopecia.
![Hair: What Is New in Diagnosis and Management?](/images/research/f720ed6b-c511-4085-8ae8-601678cf8c19/small/3252.jpg)
research Hair: What Is New in Diagnosis and Management?
Female pattern hair loss diagnosed by scalp appearance, treated with combined therapies and targeted approaches.
![The Role of Dutasteride in the Treatment of Benign Prostatic Obstruction and Related Conditions](/images/research/202e0522-6653-4d22-b2f6-bd99edc5c456/small/15240.jpg)
research The Role of Dutasteride in the Treatment of Benign Prostatic Obstruction and Related Conditions
Dutasteride effectively treats benign prostatic obstruction, improves urinary flow, reduces prostate size, and may prevent prostate cancer, but can cause sexual side effects.
![Androgenetic Alopecia: An Autosomal Dominant Disorder](/images/research/e8dbe281-d12a-4b68-ab8a-fb7c57095328/small/2059.jpg)
research Androgenetic Alopecia: An Autosomal Dominant Disorder
Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.
![Effect of Dieckol, a Component of Ecklonia Cava, on the Promotion of Hair Growth](/images/research/790427be-5a29-4f7f-88e6-64e11be75e43/small/25728.jpg)
research Effect of Dieckol, a Component of Ecklonia Cava, on the Promotion of Hair Growth
Dieckol from Ecklonia cava may help hair growth and could be a potential hair loss treatment.
![Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report](/images/research/a3b612a4-ac3d-4771-8072-495269276fc8/small/2798.jpg)
research Improvement of General Symptoms in a Chronic Psychotic Patient Treated with Finasteride: Case Report
Finasteride improved symptoms in a schizophrenia patient.
![Clinical Pharmacokinetics and Pharmacodynamics of Finasteride](/images/research/d0376049-c5e2-4021-89e3-7e873427cf00/small/2091.jpg)
research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride
Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
![Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats](/images/research/0f0b9761-695b-4f84-8c4a-39ae1f3718fa/small/31823.jpg)
research Effects of Chronic Inhibition of Testosterone Metabolism on Cardiac Remodeling After Ischemia/Reperfusion-Induced Myocardial Damage in Gonadectomized Rats
Testosterone reduces heart damage and inflammation after injury.
research Pre-Receptor Regulation of the Androgen Receptor
Two enzymes regulate androgen receptor activity, affecting treatments for androgen insufficiency and benign prostatic hyperplasia.
![The Promoting Effect of Ishige Sinicola on Hair Growth](/images/research/76b0a2de-18a6-4968-a8ab-a19b9bf70f5d/small/19016.jpg)
research The Promoting Effect of Ishige Sinicola on Hair Growth
Ishige sinicola, a type of seaweed, may help hair grow by blocking a hair loss-related enzyme and boosting important cell growth.
![Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction](/images/research/ac0c13c1-a57f-4a2e-b94a-ca835d01570a/small/18221.jpg)
research Long-Term Dutasteride Therapy in Men with Benign Prostatic Hyperplasia Alters Glucose and Lipid Profiles and Increases Severity of Erectile Dysfunction
Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.
![Recommendations on the Clinical Management of Androgenetic Alopecia: A Consensus Document from the Spanish Group of Trichology of the Spanish Academy of Dermatology and Venereology](/images/research/ef589def-921c-4ddf-a7ed-9db423c15c8f/small/26443.jpg)
research Recommendations on the Clinical Management of Androgenetic Alopecia: A Consensus Document from the Spanish Group of Trichology of the Spanish Academy of Dermatology and Venereology
Dermatologists recommend oral dutasteride for male hair loss, low-dose oral minoxidil for female hair loss, and a multidisciplinary approach for young patients, with caution during pregnancy.
![Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride](/images/research/77733181-73df-4d13-8ba3-6b71c79dac4e/small/2197.jpg)
research Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride
Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.
![Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells](/images/research/7585be92-4c9a-4fc8-ab21-a2f76f984e10/small/31729.jpg)
research Novel Type 1 5a-Reductase Inhibitors With Antiproliferative Potential On LNCaP Cells
New compounds may help treat prostate cancer by reducing cell growth.