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New CRISPR/Cas9 variants and nanotechnology-based delivery methods are improving cancer treatment, but choosing the best variant and overcoming certain limitations remain challenges.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

UV radiation damages hair by creating holes and peeling cuticle layers.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

THSG from a Chinese plant helps with aging and related diseases.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.

Analog 23 is a promising compound for prostate cancer treatment.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

New hormonal treatments for enlarged prostate show promise for safer, effective non-surgical options.

Researchers developed a reliable method to measure testosterone and epitestosterone in urine for medical and anti-doping use.

Finasteride use may lead to less alcohol consumption in men with lasting sexual side effects.

Runx1 controls fat-related genes important for normal and cancer cell growth, affecting skin and hair cell behavior.

YangHyulEum Gami-Bang extract may help treat hair loss.

The black orchid Brasiliorchis schunkeana produces chemicals that attract certain insects and have potential antimicrobial properties.

Sansevieria trifasciata Prain shows promise for treating hair loss by inhibiting androgen receptors.

The document concluded that more research is needed to understand how estrogen affects the enzyme involved in hirsutism development.

Testosterone, progesterone, and levonorgestrel change enzyme levels related to fat production in hamster skin, which could affect skin oil and acne.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Researchers made two new compounds that could be used for medicine.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Four-amino acid part makes enzyme sensitive to finasteride.

Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.