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Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

The ginseng market has potential for growth and needs new products and better marketing.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the fast-growing direct-to-consumer genetic testing market lacks sufficient regulation, posing risks to consumers due to questionable test quality and accuracy.

Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.

Low iron and L-lysine levels can cause hair loss in women, and increasing these nutrients can reduce hair shedding.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Diet changes can protect against harmful environmental effects on fetal development.

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The Rotterdam Study aims to understand various diseases in older adults.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

About 7% to 15% of Iranian women have polycystic ovary syndrome, depending on the criteria used to diagnose it.