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Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

Lifestyle changes are the main treatment for PCOS, which is a complex condition requiring early management to reduce its health impacts.

Hormonal treatments are effective as a second-line option for moderate-to-severe acne in females, but should be used with caution due to health risks.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.

With careful management, people with congenital adrenal hyperplasia can have successful pregnancies and become parents.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

Arctiin helps protect hair cells from damage and death caused by oxidative stress.

Mice with LSS deficiency showed hair loss and cataracts, similar to humans, and can help in understanding and treating this condition.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

CAH is a genetic disorder affecting cortisol production and causing hormonal imbalances, with treatment and diagnosis varying by form and symptoms.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

A new non-invasive method can analyze skin mRNA to understand skin diseases better.

Blackcurrant extract may help reduce hair loss by promoting stem cell activity in hair follicles.

Selective breeding caused the unique curly hair in Mangalitza pigs.

The research identified two types of keratinocytes in chicken scales: one for hard scales and another for soft skin, with similarities to human skin differentiation.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Sex steroids affect the MafB gene differently in male and female hamsters.

Genetic mutations can affect female sexual development, requiring personalized medical care.

HNG may help prevent the negative effects of chemotherapy on sperm production and white blood cell counts.

The Rotterdam Study investigates diseases in older adults and has produced many research findings.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.