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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Paris polyphylla saponins may effectively treat acne due to their antibacterial and anti-inflammatory properties.

5-alpha reductase inhibitors, like finasteride and dutasteride, may cause depression, but more research is needed to understand why.

A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Bicalutamide may help treat female pattern hair loss.

Vitamin D receptor is important for regulating hair growth and wound healing in mice.

Keeping β-catenin levels high in mammary cells disrupts their development and branching.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

The 2003 guidelines suggest that while some treatments can regrow hair in alopecia areata, none alter the disease's progression, and wigs may be the best option for extensive hair loss.

Patients with certain skin symptoms and high ANA titers should be monitored for potential systemic lupus.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

The document concludes that managing PCOS involves treating symptoms, regulating periods, and reducing health risks, with specific medications for fertility and metabolic issues.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Steroids help hair regrowth, and minoxidil slows post-steroid hair loss, but effects are temporary.

Oral medication is necessary to treat scalp fungus in children, with griseofulvin being the usual choice.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

Doctors should know how to diagnose and treat PCOS, which often involves checking for high male hormone levels and using medications to manage symptoms.

Hedychium spicatum has medicinal properties but needs more research for scientific validation and use.

The document concludes that primary scarring alopecias cause permanent hair loss, have unpredictable outcomes, and lack definitive treatments, requiring personalized care.

Some treatments can help hair regrowth in alopecia areata, but none offer a cure, and effectiveness varies.

Acne can be managed with various treatments and requires psychological support due to its emotional impact.

Caffeine can potentially treat common hair loss by counteracting hair follicle shrinkage caused by hormones.

High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.

5α-Reductase inhibitors do not consistently increase testosterone levels in the blood.

Endocrine therapies for cancer significantly increase the risk of hair loss.

Cyclophosphamide effectively induces cashmere shedding in goats without affecting their overall health.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.