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MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Dutasteride effectively and safely treats male hair loss for over a year.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

Curcuma aeruginosa extract combined with minoxidil effectively treats male-pattern baldness.

5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

Dutasteride is safe and effective for treating hair loss, but may decrease libido.

Compounds from the plant Mammea siamensis may help treat hair loss.

Taking 5-alpha reductase inhibitors does not increase the risk of breast cancer in men.

Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Testosterone's muscle-building effects do not require its conversion to DHT.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Certain drugs that block specific enzymes can help treat prostate diseases.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Finasteride effectively treats male pattern hair loss with a 1 mg daily dose.

Finasteride 5 mg/day effectively treats hair loss in postmenopausal women without hyper-androgenism.

Black pepper leaf extract contains compounds that can block testosterone effects and promote hair growth.

Lygodii Spora extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.

Certain 4-azasteroids are effective at blocking the enzyme that processes testosterone in human skin and could help treat acne, excessive hair growth, and male pattern baldness.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Rats had lasting erectile problems after stopping a certain medication.

Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.

This document studied minoxidil in healthy volunteers. Minoxidil is quickly absorbed and eliminated from the body.

Oral minoxidil 5 mg daily increases hair growth safely in men with hair loss, with minor side effects.

Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.