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research Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

In this study, human dermal fibroblast-conditioned medium was found to contain numerous proteins involved in wound repair and hair regeneration, with identified proteins forming interaction networks linked to key signaling pathways like epidermal growth factor receptor and transforming growth factor-β.

research Restoring dry, damaged hair with a novel natural wheat protein and wheat germ oil– containing shampoo and conditioner line

February 2010 in “Journal of the American Academy of Dermatology”

The shampoo and conditioner improved dry, damaged hair significantly after three uses.

research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this study, researchers observed that spontaneously mutated mice with a hair loss phenotype exhibited significant differential expression of genes related to keratinization and hair follicle formation, suggesting these mice could model human alopecia for future research and treatment development.

research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

November 2024 in “Biochemical and Biophysical Research Communications”

In this study, researchers observed that mutant mice with a genetic hair loss condition exhibited significant differential expression of genes related to keratinization and hair follicle formation, providing insights into potential strategies for understanding and treating alopecia.

research Risks of Protein Conditioner Application under the Impact of Heat and/or Gamma Irradiation in Albino Rats

April 2021 in “Arab Journal of Nuclear Sciences and Applications/Arab Journal of Nuclear Sciences and Applications ”

This study found that repeated use of a protein hair conditioner, followed by hot air and gamma irradiation, may lower serum collagen I and increase heat shock protein concentrations in rats, suggesting potential cumulative risks.

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Community Join

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community Shampoo + Protein shake causing hair shedding?

in Ketoconazole 1 year ago

The user started using ketoconazole shampoo and whey protein shakes and noticed increased hair shedding, seeking advice on whether these could be the cause. Another user shared their experience with hair loss after starting protein shakes and mentioned using finasteride, which eventually improved their hair condition.

community Does whey protein and creatine aggravate hair loss?

79 upvotes 2 years ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community It’s been a while, figured it’s time for a scalp check. Finasteride only progress.

346 upvotes 1 year ago

A 26-year-old has been using finasteride for over two years, initially at 1.25mg daily and later at 5mg weekly, resulting in stable hair condition with some regrowth and minimal side effects. The user reports high libido and a protein and vegetable-heavy diet, with initial watery semen as the only side effect.

community Dut and min not working, what’s next?

2 upvotes 1 month ago

A 21-year-old male has been using finasteride, dutasteride, and oral minoxidil for hair loss without success and is considering trying RU58841, pyrilutamide, or clascoterone. Another user suggests checking vitamin levels, health conditions, and protein intake.

community Hi-c5 protein, explains why the mechanical tension theory may be correct.

22 upvotes 1 month ago

Hair loss may be influenced by mechanical tension and inflammation, with the hi-c5 protein amplifying androgen effects, leading to follicle miniaturization. Treatments like finasteride, minoxidil, and scalp massages are suggested to manage hair loss.

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Learn

6 / 21 results

learn Verteporfin

Light-activated eye drug being studied for scarring

learn Keratin

What role does keratin play in strengthening weak or thinning hair? Keratin is the protein hair is made of. Keratin products can make existing hair look smoother and break less, but they do not prevent thinning or hereditary hair loss.

learn SCUBE3

Signalling protein made in the hair follicle

What is SCUBE3 and why is it being studied as a potential breakthrough for hair regrowth? SCUBE3 is a signaling protein that made resting hair follicles start growing in mouse experiments in a 2022 study. It has not been tested in people and is not an approved treatment.
How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor is a signalling protein linked to hair colour in lab and mouse studies; it is not a proven hair-loss treatment in people.

learn Follistatin

Protein that blocks activin, a growth-regulating signal

What is follistatin, and how does it influence hair follicle growth and regeneration? Follistatin blocks activin and related growth-inhibiting proteins, which mouse studies link to hair follicle development and cycling; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.

learn Osteopontin

Signalling protein studied in hair-growth research

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas