Dut and min not working, what’s next?
    8/19/2026

    From the encyclopedia
    Finasteride →

    Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

    Dutasteride →

    5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

    Minoxidil →

    Vasodilator used on the scalp and, at low doses, as a tablet

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💊 Finasteride (oral) 8 months
    💊 Dutasteride (oral) 1 year
    💊 Minoxidil (oral) 8 months
    the tone is 😞 negative with no growth results.

    Other terms

    A 21-year-old male has been using finasteride, dutasteride, and oral minoxidil for hair loss without success and is considering trying RU58841, pyrilutamide, or clascoterone. Another user suggests checking vitamin levels, health conditions, and protein intake.
    View this post in the Community →

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    6 / 6 results

      community Laser Diode Cap, I already use Oral Fin, Topical Min 5%, Nizoral and Microneedling

      in Treatment  1 upvotes 10 months ago
      The user is seeking advice on maximizing hair growth while using oral finasteride, topical minoxidil, Nizoral, and microneedling, and is considering adding a laser diode cap, topical finasteride, retinol, and caffeine. Suggestions include using tretinoin with minoxidil for better absorption, switching to dutasteride, and considering RU58841 or pyrilutamide.

      community Finasteride stopped working, I'm switching to oral Dutasteride

       69 upvotes 1 year ago
      The user switched from Finasteride to topical Dutasteride, Pyrilutamide, and Minoxidil due to hair loss, then decided to switch to oral Dutasteride because of pregnancy concerns. They are considering the frequency of oral Dutasteride use, with suggestions of using it a few times a week for better results and fewer side effects.

      community Possibilities without Fin/Dut ?

       5 upvotes 7 months ago
      The user experiences severe side effects from finasteride and dutasteride, including low libido and anxiety, and is currently using oral minoxidil despite shortness of breath. They are seeking alternative treatments for hair loss, having tried pyrilutamide, fluridil, and RU58841 with no success, and are considering future treatments or a hair transplant.

      community I Think it is Over for me Bros. I'm Cooked.

      in Finasteride/Dutasteride  49 upvotes 1 year ago
      A 24-year-old user tried finasteride, oral minoxidil, and dutasteride for hair loss but saw no improvement and was advised by their dermatologist to accept baldness. Other users suggested alternative treatments like RU58841, pyrilutamide, microneedling, and checking for underlying conditions or lifestyle factors.

      community M23: Oral min and fin 6months + no regrowth or progress

       38 upvotes 2 weeks ago
      The user has been using oral minoxidil and finasteride for 6 months with no regrowth and increased shedding, and recently switched to a higher dose of minoxidil. Suggestions include switching to dutasteride, adding topical anti-androgens like RU58841, and considering a hair transplant.

    Related Research

    6 / 6 results

      research Nouvelles thérapeutiques dans la prise en charge de l’alopécie androgénétique

      March 2025 in “HAL (Le Centre pour la Communication Scientifique Directe)”
      This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.

      research CLINICAL UPDATES IN HAIR

      19 citations , January 1997 in “Dermatologic Clinics”
      This chapter reviews various antiandrogens and androgen inhibitors, detailing their mechanisms, uses, and side effects, with a focus on spironolactone, finasteride, dutasteride, and oral contraceptives.

      research Antiandrogens and Androgen Inhibitors

      November 2020 in “Elsevier eBooks”
      This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

      research Тіе Modern treatment of androgenetic alopecia

      February 2017 in “Vestnik dermatologii i venerologii”
      This review examines the molecular mechanisms and current treatment options for androgenetic alopecia, highlighting potential future therapies but providing no new experimental findings.