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Glossaryp27Kip1

protein that inhibits cell cycle progression by regulating CDKs

p27Kip1, also known as p27 or CDKN1B, is a protein that helps regulate the cell cycle by inhibiting cyclin-dependent kinases (CDKs). This regulation is crucial for controlling cell growth and division, and disruptions in p27Kip1 function can lead to uncontrolled cell proliferation, which is a hallmark of cancer.

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research Cyclin-dependent kinase inhibitors, p21waf1/cip1 and p27kip1, are expressed site- and hair cycle-dependently in rat hair follicles

9 citations , February 2001 in “Journal of Dermatological Science”

p21waf1/cip1 and p27kip1 help in hair follicle differentiation in rats.

research Bone Morphogenetic Protein Signaling Regulates the Size of Hair Follicles and Modulates the Expression of Cell Cycle-Associated Genes

92 citations , November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

BMP signaling controls hair follicle size and cell growth by affecting cell cycle genes.

research Brg1 Governs a Positive Feedback Circuit in the Hair Follicle for Tissue Regeneration and Repair

52 citations , April 2013 in “Developmental Cell”

Brg1 is crucial for hair growth and skin repair by maintaining stem cells and promoting regeneration.

Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

research Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix

30 citations , April 2017 in “European Journal of Cell Biology”

CIP/KIP proteins help stop cell division and support hair growth.

research Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro

19 citations , April 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

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