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Glossary Mass Spectrometry

measures mass-to-charge ratios of ions in a sample

Mass Spectrometry (MS) is an analytical technique used to measure the mass-to-charge ratio of ions. It helps identify the composition of a sample by generating a spectrum that displays the masses of its components, making it invaluable in fields like chemistry, biology, and medicine for detecting and quantifying molecules, including proteins and metabolites.

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Research

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Evaluation of Contamination and Quantification of Drug Penetration Studies Using Quantitative Mass Spectrometry Imaging

research 686 Evaluation of contamination and quantification of drug penetrations studies using Quantitative Mass Spectrometry Imaging

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that Quantitative Mass Spectrometry Imaging offers precise localization and quantification of active compounds in skin tissues, demonstrating benefits over traditional LC-MS in drug penetration studies.

research Investigation by Imaging Mass Spectrometry of Biomarker Candidates for Aging in the Hair Cortex

21 citations , October 2011 in “PloS one”

In this study, researchers identified three molecules in hair that varied with age, suggesting potential markers for aging and targets for cosmetic products.

research 144 Evaluation of contamination and quantification of drug penetrations studies using Quantitative Mass Spectrometry Imaging

September 2017 in “Journal of Investigative Dermatology”

QMSI effectively maps and quantifies drug distribution in skin tissues.

MALDI Imaging Mass Spectrometry of Skin: Aspects of Sample Preparation

research MALDI (matrix assisted laser desorption ionization) Imaging Mass Spectrometry (IMS) of skin: Aspects of sample preparation

30 citations , June 2017 in “Talanta”

This review discusses the critical parameters for MALDI IMS sample preparation in skin analysis and highlights its applications in wound healing, neoplasia, and infection research, but reports no new clinical results.

research In-Situ Imaging Mass Spectrometry Analysis of Melanin Granules in the Human Hair Shaft

50 citations , February 2004 in “Journal of Investigative Dermatology”

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community Unexpected Serum DHT Elevation after Generic Dutasteride Use.

in Finasteride/Dutasteride 38 upvotes 1 year ago

Switching from finasteride to a generic dutasteride led to unexpectedly high DHT levels, prompting a switch to a reputed brand and consideration of softgel capsules for better absorption. The user plans to retest DHT levels and may return to finasteride if issues persist.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

158 upvotes 2 years ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community hairloss treatment, what to expect (bloodwork)

1 upvotes 11 months ago

The conversation discusses hair loss treatment options, focusing on finasteride and its potential effects on gynecomastia. The user is considering finasteride while managing hormone levels with supplements like boron, vitamin D, zinc, magnesium, and P5P, and is advised to consult an endocrinologist for further evaluation.

community Finasteride does deplete important nuero-active steroids

11 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community Liquid Chromatography–Mass Spectrometry (LC-MS) VS Enzyme-Linked Immunosorbent Assay (ELISA)

5 upvotes 1 year ago

Finasteride and Nizoral shampoo with Ketoconazole are used for hair loss treatment. Liquid Chromatography–Mass Spectrometry (LC-MS) is recommended over Enzyme-Linked Immunosorbent Assay (ELISA) for more accurate DHT testing.

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