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Did you mean Lymphoid Enhancer-Binding Factor 1?

GlossaryLymphoid Enhancer-Binding Factor 1

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor

37 citations, April 2011 in “Journal of Biological Chemistry”

LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.

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