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Glossary Keratinization

process where skin cells produce keratin and become tough

Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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research In vivo formation steps of the hard α-keratin intermediate filament along a hair follicle: Evidence for structural polymorphism

22 citations , January 2006 in “Journal of Structural Biology”

Hair follicles form hard α-keratin filaments in four steps, showing structural differences.

research Immunohistochemical staining characteristics of epidermal appendages (hair follicles and eccrine sweat glands) to anti-epidermal keratin antisera

6 citations , November 1984 in “Acta Dermato Venereologica”

This study investigated the immunohistochemical characteristics of keratin proteins in epidermal appendages, finding variable staining patterns in different skin structures and tumor cells, which suggests differences in keratinization.

research 성장기 모낭에서 큐티클층의 각질화 과정

January 2017 in “대한미용학회지”

This study observed that hair follicle cuticular cells undergoing keratinization were significantly thicker than those in a normal hair shaft, due to incomplete loss of cytosol.

research Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization.

59 citations , August 1981 in “PubMed”

This study describes trichilemmal keratinization as a distinct process of hair follicle keratinization that occurs in specific areas of the outer root sheath, illustrated using electron microscopy on dog hair.

research Study of the keratinization process in human hair follicle by X-ray microdiffraction.

28 citations , July 2000 in “PubMed”

This study found no structural differences between in vitro and in vivo grown hair, with keratinization and organization of keratin being comparable in both settings.

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