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research 294 Extensive alopecia areata is reversed by IL-12/23p40 cytokine antagonism

April 2016 in “Journal of Investigative Dermatology”

In this study, three patients with extensive alopecia areata receiving ustekinumab treatment showed significant hair regrowth and decreased inflammation over 20 weeks, suggesting potential targeted treatment for this condition.

research Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism

68 citations , November 2015 in “The Journal of Allergy and Clinical Immunology”

In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.

research IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans

20 citations , December 2019 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

In this study, ustekinumab did not promote hair regrowth in human patients with alopecia areata or prevent disease development in an AA mouse model, suggesting limited efficacy for this treatment.

An Integrated Model of Alopecia Areata Biomarkers Highlights Both Th1/Th2 Upregulation, with Stronger Correlations Between Th2 Activation and Disease Severity

research 1315 An Integrated model of alopecia areata biomarkers highlights both Th1/Th2 upregulation, with stronger correlations between Th2 activation and disease severity

April 2018 in “Journal of Investigative Dermatology”

This study found that both Th1 and Th2 cytokine markers were elevated in the serum and skin of patients with alopecia areata, with Th2 markers more closely linked to disease severity.

research Biomarkers of alopecia areata disease activity and response to corticosteroid treatment

65 citations , December 2015 in “Experimental dermatology”

This study found that both Th1 and Th2 immune responses, along with IL-23 and IL-32 cytokine pathways, are active in alopecia areata lesions, and corticosteroid injections significantly altered these immune markers.

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Experts

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Community Join

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community 12 mo update: oral (dut, min), topical (RU, min), microneedling

356 upvotes 3 years ago

A user's 12 month update on treatment for hair loss, which include oral dutasteride and minoxidil, topical RU88541 and minoxidil, microneedling with hyaluronic acid and FinDuta, experiencing no side effects, positive results and inspiring other users.

community [30M] Regenera Activ (7 Weeks) + Topical Dutasteride/Minoxidil (12 Weeks)

in Progress Pictures 187 upvotes 1 year ago

A 30-year-old man shared his positive experience with hair regrowth using Regenera Activ, topical Dutasteride, Minoxidil, and PRP over 12 weeks. He plans to continue with injectable Dutasteride and emphasizes the importance of starting treatment early to combat hair loss.

community 4 months!! We making progress!!

506 upvotes 1 year ago

A user shared their successful hair regrowth journey using 0.5 mg Dutasteride, 2.5 mg oral Minoxidil, and Biotin gummies, after switching from Finasteride due to insomnia. They highlighted the importance of brushing the scalp for blood flow and reported significant progress in four months without side effects.

community Failed HT or expected result? 4505 grafts, Eugenix, New Delhi.

in Transplants 36 upvotes 1 year ago

The hair transplant at Eugenix in New Delhi resulted in poor density and texture, with only about 2,500 grafts surviving out of 4,500. The user is considering holding the clinic accountable and exploring options like shaving, using hair fibers, or seeking another transplant.

community Pls advice needed. 17-20 yo. Not seeing the progress I hoped for on finasteride + minoxidil. Any advice?

in Progress Pictures 22 upvotes 6 months ago

A user is experiencing hair loss despite using topical minoxidil, oral finasteride, and 2% ketoconazole shampoo, and is seeking advice on further treatments. Suggestions include switching to dutasteride, trying oral minoxidil, addressing scalp inflammation, and considering dietary changes and supplements.

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Learn

2 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

What happens after a hair transplant? Expect mild swelling and redness, with new hair growth starting in 3 to 6 months.

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Clinics

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