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research Effects of recombinant human keratinocyte growth factor-2 on hair regeneration in experimental bald rats

January 2012

In this study, rhKGF2 significantly promoted hair regeneration and enhanced the formation and maturation of hair follicles in experimental bald rats, suggesting potential clinical application.

N,N-Dimethylglycine Sodium Salt Exerts Anti-Inflammatory Effects in Dermatitis Models and Activates Human Epidermal Keratinocytes

research N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release

July 2023 in “International Journal of Molecular Sciences”

This study found that N,N-dimethylglycine sodium salt promoted proliferation and migration of cultured human epidermal keratinocytes and had anti-inflammatory and antioxidant effects in vitro.

research Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue¹

4 citations , June 1998 in “The Journal of Clinical Endocrinology & Metabolism”

This study found that keratinocyte growth factor is a potent mitogen in human hyperplastic prostate cells, suggesting it plays an important role in prostate growth by acting in a paracrine manner.

Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

research Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair folliclesin vitro

60 citations , May 2014 in “British Journal of Dermatology”

This study found that caffeine enhanced hair growth and keratinocyte proliferation in human hair follicles, with female follicles showing greater sensitivity than male ones.

Growth Factors IGF-1 and KGF and Adipose-Derived Stem Cells Promote Migration and Viability of Primary Human Keratinocytes in an In Vitro Wound Model

research Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model

8 citations , February 2025 in “Frontiers in Medicine”

This study suggests that using growth factors and ADSC-conditioned medium can enhance keratinocyte viability and migration in epidermal transplantation, potentially improving chronic wound healing rates with a patient-dependent effect.

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Community Join

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community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Painkillers May Block Minoxidil

12 upvotes 1 year ago

Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

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Learn

8 / 23 results

learn Epidermal Growth Factor

learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.
How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Thymosin Beta 4

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn GHK-Cu

What is GHK-Cu and why is it said to be a "miracle" for hair? GHK-Cu is a copper peptide studied mainly for wound healing and skin repair; for hair loss the evidence stops at cell-culture and animal work, and no published human trial has tested it for androgenetic alopecia.

learn Biotin

Biotinyl-GHK: a miracle ingredient against hair loss? Biotinyl-GHK (biotinoyl tripeptide-1) is a cosmetic ingredient, not an approved hair-loss medicine; the published studies test it only inside multi-ingredient complexes such as Procapil, so no result can be attributed to the peptide itself.

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