research Differences of Superoxide Dismutase (SOD) Enzyme Levels Based on the Severity of Androgenetic Alopecia in Men
This article discusses androgenetic alopecia's mechanisms but reports no new study results.
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research Gender differences in skin: A review of the literature
This review discusses recent advances in understanding gender differences in skin and their implications for dermatologic diseases, but it reports no new experimental results; ongoing research is necessary for translating these insights into clinical practice.
research Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role
This review discusses the sex differences in neuroactive steroid synthesis and their implications for nervous system functions and potential therapeutic approaches, but it provides no new experimental results.
research Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase
This study suggests that the susceptibility of hair follicle melanocytes to oxidative stress as they age may be key in the graying of hair due to reduced catalase expression and activity.
research Rapid high-performance liquid chromatogaphic method for detection of interindividual differences in carcinogen metabolism
This study found that enzyme activity related to cancer induction by polycyclic aromatic hydrocarbons can be increased by using a shampoo containing crude coal tar and significantly inhibited by imidazole compounds in human hair follicles.
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5 / 726 resultscommunity Who won’t respond to minoxidil? (Studies)
Minoxidil's effectiveness varies due to differences in sulfotransferase enzyme levels in the scalp, affecting people with conditions like ASD, liver disease, and androgenic alopecia. Treatments like topical tretinoin, microneedling, and using minoxidil sulfate instead of regular minoxidil can improve results for those with low enzyme levels.
community Oral Minoxidil - The Hyper-Responder Concept
Minoxidil's effectiveness varies due to genetic differences in the SULT1A1 enzyme, affecting how well it converts to its active form, minoxidil sulfate. Hyper-responders may experience rapid hair growth and increased side effects, such as pericardial effusion, even at low doses.
community Oral Minoxidil Changes to Vellus Hair
A person in their early 30s has been using finasteride for about 10 years and recently started oral minoxidil, vitamin chewables, and dermarolling to address hair loss. They noticed pigmented vellus hairs and potential regrowth, questioning if oral minoxidil is more effective than topical due to enzyme differences.
community Fix/min after 9 months - can you spot the difference?
The user experienced significant hair regrowth after using minoxidil for 9 months and finasteride for 3 months, with plans to continue treatment and possibly get a hair transplant. Some users suggested adding microneedling and other treatments, while others discussed potential side effects of finasteride.
community Increasing activity of the sult1a1 enzyme via alkalizing agent and tretinoin for better response to topical minoxidil
Increasing the sult1a1 enzyme on the scalp may improve response to topical minoxidil. The user suggests using a baking soda solution, DMSO, and tretinoin to enhance enzyme activity and minoxidil effectiveness.
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4 / 801 results- Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.
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