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research Depression Risk in the Treatment of Moderate to Severe Acne with Isotretinoin

2 citations , July 2019 in “Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg)”

This article reviews the use of isotretinoin for acne treatment and its controversial association with depression and suicide, noting limited evidence for a direct link.

research Depression risk of 5-alpha reductase inhibitors: impact of active-comparator versus non-drug user control groups on risk measurement

February 2026 in “Postgraduate Medicine”

This meta-analysis reports that 5-alpha-reductase inhibitors are associated with a 31% increased risk of depression, with varying outcomes depending on the comparator group, highlighting significant heterogeneity across studies.

research Depression risk of 5-alpha reductase inhibitors: A systematic review and meta-analysis with a focus on comparator groups

August 2025 in “medRxiv (Cold Spring Harbor Laboratory)”

This study reports that using 5-alpha reductase inhibitors is associated with a 31% increased risk of depression, highlighting that the choice of comparator group significantly affects study results.

research Finasteride: risk of suicidality and depression

June 2025 in “Reactions Weekly”

Finasteride may increase the risk of depression and suicidal thoughts.

research Risk of Depression Associated With Finasteride Treatment

7 citations , April 2021 in “Journal of Clinical Psychopharmacology”

In this study, finasteride treatment was associated with an increased risk of depression, suicidal ideation, and persistent sexual dysfunction compared to those not treated with the drug.

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community Popular hair loss drug linked to higher suicide risk: compared to non-users, finasteride (Proscar/ Propecia) users have a markedly increased risk of depression, anxiety, and suicidal thoughts. Over 30 years of observation, 19,320 suicides were expected.

494 upvotes 11 months ago

Finasteride users may have an increased risk of depression, anxiety, and suicidal thoughts, though some attribute these issues to hair loss itself. The link between finasteride and mental health effects is debated, with varying user experiences.

community The EU has Finasteride and Dutasteride under review at risk of getting banned.

in Finasteride/Dutasteride 159 upvotes 1 year ago

Finasteride and Dutasteride are under review in the EU due to concerns about side effects like depression, but they are unlikely to be banned. Access to these medications varies, with easier availability in the UK compared to some EU countries.

community Hair Loss Ruins Your Mind: 10x rate of BDD. PF S is not real

in Research/Science 39 upvotes 7 months ago

Hair loss is linked to a higher rate of body dysmorphic disorder (BDD), OCD, and depression. Finasteride and dutasteride are not linked to increased suicidal risk, though some users report mental health side effects.

community Hair Loss Causes Depression. Not Finasteride.

187 upvotes 7 months ago

Finasteride and Dutasteride do not cause depression or mood disorders; hair loss itself may be a more significant factor. Some users experience side effects from Finasteride, but it is generally well-tolerated.

community Should I risk changing to Dutasteride?

in Finasteride/Dutasteride 10 upvotes 1 year ago

The user is considering switching from Finasteride to Dutasteride for better hair regrowth, despite concerns about potential shedding and side effects. Opinions vary, with some suggesting the switch for stronger results and others advising caution due to possible side effects and the importance of consulting a doctor.

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learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

Is finasteride safe? In one-year trials most men tolerated finasteride 1 mg, but its risks are not only sexual: US, UK and EU regulators warn of sexual dysfunction, depression and suicidal thoughts, and of sexual and mood symptoms that have continued after stopping, and men also report cognitive, anxiety and physical symptoms. How often lasting problems happen, and how much of that the drug causes, is not known; finasteride is prescription-only and must not be taken, or handled as crushed or broken tablets, by women who are or may be pregnant.

learn Dutasteride

5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

Is it dangerous to buy dutasteride without a prescription? Dutasteride is a prescription medicine, and its US label warns about a PSA drop, a higher rate of high-grade prostate cancer in one trial, sexual and breast side effects (the sexual ones may persist after stopping, with dutasteride's role unknown), depressed mood and a new UK class warning about depression and suicidal thoughts, risks in pregnancy and a 6-month blood-donation deferral. Buying from unregulated online sellers adds the risk of counterfeit or contaminated products.

learn Mesotherapy

Injections of drug or vitamin mixtures into the scalp

learn Hair Transplant

Surgery that moves hair follicles from the back of the scalp to thinning areas

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