TLDR No proven link between isotretinoin and depression.
The document discussed the use of isotretinoin, a treatment for moderate to severe acne, which was effective but controversial due to its potential link to depression and suicide. Despite being the most effective treatment since 1982, there was a lack of evidence-based research to confirm a positive correlation between isotretinoin and depression or suicide. The compound, a vitamin A analog, could cross the blood-brain barrier and affect brain areas related to depression. Animal studies showed mixed results regarding isotretinoin's impact on depression-related behavior, indicating the need for further research.
73 citations
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March 2014 in “Journal of The American Academy of Dermatology” Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.
138 citations
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June 2023 in “Molecules” Skin pigmentation varies due to genetics, UV exposure, and drugs, with treatments available but requiring medical advice.
4 citations
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March 2002 in “Journal of the American Pharmaceutical Association” The conclusion is that pharmacists are important in helping women choose the right skin care treatments.
2 citations
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March 2016 in “Obstetrics and Gynecology Clinics of North America” The document says that common skin conditions in adult women can be treated effectively, with acne being the most common and early-detected melanoma having a high survival rate.
8 citations
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January 1996 in “Gynecological Endocrinology” Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.