The Hair Loss Encyclopedia

Depression Risk in the Treatment of Moderate to Severe Acne with Isotretinoin

July 2019 in “ Digital Showcase Research, Scholarship, & Creative Works (University of Lynchburg) ”

Volz, Joleen Michelle

isotretinoin acne vitamin A analog blood-brain barrier Accutane

TLDR No proven link between isotretinoin and depression.

The document discussed the use of isotretinoin, a treatment for moderate to severe acne, which was effective but controversial due to its potential link to depression and suicide. Despite being the most effective treatment since 1982, there was a lack of evidence-based research to confirm a positive correlation between isotretinoin and depression or suicide. The compound, a vitamin A analog, could cross the blood-brain barrier and affect brain areas related to depression. Animal studies showed mixed results regarding isotretinoin's impact on depression-related behavior, indicating the need for further research.

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