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    Did you mean SMAD4?
    Glossary SMAD4

    protein involved in TGF-beta signaling, affecting cell growth and differentiation

    SMAD4, also known as Mothers against decapentaplegic homolog 4, is a protein that plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, differentiation, and apoptosis. Mutations in the SMAD4 gene can lead to various medical conditions, including certain types of cancer and hereditary hemorrhagic telangiectasia.

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      community My Theory Of Androgenic Alopecia

       16 upvotes 9 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community 4 years wearing hair systems - what nobody tells you when you start

       227 upvotes 6 months ago
      Hair systems require frequent maintenance and can be costly, but a DIY approach with bi-weekly changes can help manage these issues. Minoxidil and finasteride were tried but not consistently used due to side effects and personal preferences.

      community What foods do you feel have helped you get essential nutrients?

       1 upvotes 7 months ago
      Common foods that may support hair growth include ginger shots, salmon, roasted chicken, spinach, tinned sardines, and grass-fed ground beef. Energy drinks are considered bad, and iced coffee is suggested as a possible alternative.

      community Potential pp405 info next week at masters of athetics

       53 upvotes 9 months ago
      Discussion on hair loss treatments, focusing on pp405, with skepticism about its effectiveness and concerns about its association with the cosmetic industry. Users also mention treatments like Minoxidil and Finasteride.

      community Won’t pp405 and gt20029 be patented and be almost unreasonably expensive

       29 upvotes 1 year ago
      Concerns about the potential high cost of new hair loss treatments, pp405 and gt20029, were discussed, with some users willing to pay a premium if they are effective. Alternatives like finasteride and minoxidil are mentioned as current, more affordable options, and there is speculation about future generic versions and black market availability.

      community Journey from bald to not bald.

      in Progress Pictures  157 upvotes 1 year ago
      A user shared their successful hair transplant experience from Medart Hair Istanbul, where they received 4500 grafts and are pleased with the natural results. They also use finasteride and minoxidil in an all-in-one pill to maintain their hair.

      community 1 month oral Minoxidil & Finasteride results

      in Update  178 upvotes 1 year ago
      The user reported positive results after one month of using oral Minoxidil and Finasteride, along with Nioxin shampoo and liquid collagen. Some users expressed skepticism about the results, attributing them to lighting differences, while others discussed potential side effects and benefits of these treatments.

      community 3 month progress on min + fin capsule

      in Is this regrowth?  400 upvotes 1 year ago
      The user experienced significant hair regrowth in three months using a capsule containing minoxidil and finasteride. They reported no major side effects and plan to continue the treatment until their late 20s.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

       59 upvotes 5 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Creatine's effect on Hair Loss and DHT

       103 upvotes 2 years ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Will dht levels increased by creatine cancel out with finasteride

       8 upvotes 1 year ago
      Creatine may increase DHT levels, but its impact on hair loss is unclear and not well-studied. Many users report no significant hair loss while using creatine alongside finasteride, though some experience increased shedding.

      community What's your option on complementary treatment

       3 upvotes 2 years ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community Attention Finasteride / Dutasteride and Your liver

       374 upvotes 1 year ago
      Finasteride may cause elevated liver enzymes, potentially leading to liver issues, though this is rare. Users should monitor liver function and consider topical alternatives if liver sensitivity occurs.

      community Amplifica: Hope or Cope? A Review of Their Pipeline

       9 upvotes 1 month ago
      Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

      community Should I take creatine if Im on fin?

       9 upvotes 1 year ago
      Creatine is unlikely to worsen hair loss for those on finasteride, with no strong scientific evidence linking it to increased hair loss. Many users report no negative effects on hair while using creatine.

      community Does Creatine Really Increase DHT? My Personal Experiment

       115 upvotes 1 year ago
      Creatine does not increase DHT levels, but some report hair loss when using it, possibly due to other factors. The effects on hair loss vary individually, with no clear connection established.

      community HopeMed (Hmi115) is pissed at Absci (Abs-201)

       4 upvotes 2 weeks ago
      HopeMed is upset with Absci for allegedly using misleading information about HMI-115's performance compared to ABS-201. HopeMed plans to take legal action to protect its confidential data and trade secrets.

      community Roomate found my meds and made fun of me

      in Chat  351 upvotes 1 year ago
      A college student is embarrassed after their roommate found and mocked their hair loss medications, including Minoxidil and finasteride. The student is advised to report the privacy violation and consider finding a new roommate.

      community I’m convinced that smile is aimed straight at bald people

      in Satire  131 upvotes 4 months ago
      The conversation humorously discusses hair loss, focusing on the envy of an older man, Massimo Cacciari, who has a full head of hair. Treatments mentioned include finasteride, minoxidil, RU58841, and hair transplants, with some users expressing dissatisfaction with baldness and considering various solutions.

      community Just spilled my minoxidil while using it :-)

      in Satire  7 upvotes 4 months ago
      A user humorously lamented spilling their minoxidil, describing it as a dramatic and personal loss. Others shared similar experiences and advised caution if pets are around.

      community It's all so frustrating: I don't know what to do anymore.

      in Chat  18 upvotes 7 months ago
      The user is frustrated with hair loss despite using minoxidil, topical finasteride, and topical dutasteride, and is considering other options like oral treatments, SMP, or hair systems. They feel demoralized and are struggling with self-esteem and social interactions due to their thinning hair.

      community I am about to cry, umI hate my gens

      in Chat  58 upvotes 1 year ago
      Hair loss affects confidence, with discussions on treatments like finasteride, minoxidil, and RU58841. Emphasis is placed on self-acceptance and building confidence beyond appearance.

      community M24, very mentally unwell and I don’t know what to do

      in Chat  13 upvotes 1 month ago
      A 24-year-old is struggling with severe mental distress due to hair loss despite using dutasteride, oral minoxidil, and having a hair transplant. Many responders suggest focusing on mental health, trying different hairstyles, and accepting imperfections.