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Glossary Androgen Metabolites

byproducts formed when body breaks down male sex hormones

Androgen metabolites are the byproducts formed when the body breaks down androgens, which are male sex hormones like testosterone. These metabolites can influence various bodily functions, including hair growth and skin health, and are often studied to understand conditions like androgenic alopecia (pattern hair loss).

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Research

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research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach

November 2022 in “Journal of Herbal Medicine”

This study suggests that three mushroom-derived bioactive compounds, Zhankuic acid A, Sterenin M, and Melleolide K, may effectively inhibit SRD5A2 and stabilize its interaction, indicating potential for treating androgenic alopecia.

research Causal effects of genetically determined metabolites on androgenetic alopecia: A two‐sample Mendelian randomization analysis

May 2024 in “Skin research and technology”

This study used Mendelian randomization analysis to identify Scyllo-inositol and Alpha-ketoglutarate as potential protective factors and Heme and 2-palmitoylglycerophosphocholine as risk factors for androgenic alopecia, suggesting a causal link between these metabolites and the condition.

research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach

March 2022 in “Research Square (Research Square)”

This study found that certain bioactive mushroom metabolites may inhibit the enzyme SRD5A2 more effectively than finasteride in computational models, suggesting potential for further research in treating androgenic alopecia.

research Testosterone metabolite nonessential for androgen effects

2 citations , March 2012 in “Nature Reviews Endocrinology”

The body's change of testosterone into DHT is not necessary for testosterone's muscle and sexual effects.

research Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation

November 2025 in “Free Radical Biology and Medicine”

This study identified ten potential therapeutic targets and biomarkers for androgenic alopecia, with SOD1 and KL as particularly promising candidates for future therapies.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Spanish dermatologist suggests sulforaphane for AGA

in Research/Science 13 upvotes 2 years ago

A Spanish dermatologist suggests sulforaphane for androgenetic alopecia (AGA) due to its potential to remove DHT metabolites, though high dosages are needed. A topical formulation might be possible.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 1 year ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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Learn

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learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn Overview

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Argan oil

Argan oil: Is it useful for androgenic alopecia, or just for making hair look nice? Argan oil primarily improves hair appearance but lacks proven effectiveness for androgenic alopecia.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Metformin has been shown to lower circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

learn Microneedling

Does microneedling help with all types of alopecia, or only androgenic alopecia? Microneedling is most effective for androgenic alopecia, with limited evidence for other types.

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