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    Wnt/β-Catenin Pathway in Tissue Injury: Roles in Pathology and Therapeutic Opportunities for Regeneration

    June 2016 in “ The FASEB Journal ”
    Dikshya Bastakoty, Pampee P. Young
    Studysummary This review discusses the dual role of the Wnt/β-catenin pathway in mammalian tissue injury, highlighting its potential for both promoting regeneration and contributing to fibrosis, but presents no new findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Inhibition of Wnt/β-Catenin Pathway Promotes Regenerative Repair of Cutaneous and Cartilage Injury The FASEB Journal · 2015
    2. Targeting the Wnt Pathways for Therapies Molecular and cellular therapies · 2014
    3. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    4. Progeny of Lgr5-Expressing Hair Follicle Stem Cell Contributes to Papillomavirus-Induced Tumor Development in Epidermis Oncogene · 2012
    5. Wnt1/β-Catenin Injury Response Activates the Epicardium and Cardiac Fibroblasts to Promote Cardiac Repair The EMBO Journal · 2011
    6. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    7. Epidermal Stem Cell Diversity and Quiescence EMBO molecular medicine · 2009
    8. Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin ˜The œAmerican journal of pathology · 2009
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    11. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999