94 citations
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June 2016 in “The FASEB Journal” This review discusses the dual role of the Wnt/β-catenin pathway in mammalian tissue injury, highlighting its potential for both promoting regeneration and contributing to fibrosis, but presents no new findings.
March 2024 in “Vestnik Rossijskogo universiteta družby narodov. Seriâ Agronomiâ i životnovodstvo” In this study, the researchers used a transgenic mouse model to examine how Wnt and Shh signalling impact skin tumour development when BMP is inhibited, finding that inhibiting Wnt and Shh pathways significantly slows tumour formation in these mice.
July 2026 in “Current Pharmaceutical Design” This review highlights the therapeutic potential of medicinal plants, such as Eclipta alba and Ginkgo biloba, for managing alopecia through various molecular mechanisms, but stresses the need for further clinical trials to confirm their safety and efficacy as alternatives to synthetic treatments.
5 citations
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October 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, the authors found that inhibiting Cdc42 activity with CASIN restored hair follicle stem cell function and hair growth in aged mice, suggesting potential for treating aging-related hair regeneration issues.
41 citations
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August 2015 in “The FASEB Journal” The researchers reported that topical application of small-molecule Wnt inhibitors significantly reduced fibrosis and promoted regenerative wound healing in mice.