Male Pattern Baldness: An Update

January 2009 in “ Revista de Ciências Médicas ”

Fabiane Mulinari‐Brenner, Ivy Faigle Soares

androgenetic alopecia male pattern baldness androgen receptor hair growth cycles miniaturization minoxidil Rogaine

Studysummary This review summarizes various treatment options for male androgenetic alopecia, noting that few demonstrate effective results, and reports no new clinical findings.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Association of Androgenetic Alopecia and Hypertension

34 citations , August 2007 in “PubMed”

This study found a strong association between androgenetic alopecia and hypertension in Caucasian men, independent of age.

research A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification

125 citations , May 2007 in “Journal of The American Academy of Dermatology”

This study describes the development of the BASP classification system, providing a universal and systematic approach for classifying pattern hair loss in both men and women.

Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women

research Comparison of the Efficacy and Safety of Topical Minoxidil and Topical Alfatradiol in the Treatment of Androgenetic Alopecia in Women

56 citations , April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft”

This study found that 12 months of minoxidil treatment increased hair density and thickness in women with androgenetic alopecia, while alfatradiol primarily stabilized hair loss.

research Use of the Pulsed Infrared Diode Laser (904 nm) in the Treatment of Alopecia Areata

63 citations , January 2006 in “Journal of cosmetic and laser therapy”

This study found that pulsed infrared diode laser therapy (904 nm) was effective in promoting hair regrowth in 94% of patients with resistant patches of alopecia areata.

research Premature Androgenic Alopecia and Insulin Resistance: Male Equivalent of Polycystic Ovary Syndrome?

12 citations , December 2005 in “PubMed”

This study suggests that some men with premature androgenic alopecia may have hormonal profiles similar to women with polycystic ovary syndrome, potentially indicating a male equivalent of the condition.

research Fluridil, A Rationally Designed Topical Agent For Androgenetic Alopecia: First Clinical Experience

17 citations , August 2002 in “Dermatologic Surgery”

This study found that topical fluridil increased the anagen hair percentage in men with androgenetic alopecia without causing irritation or systemic absorption over 9 months.

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

65 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

This study found that 60% of men with mild to moderate androgenetic alopecia showed improvement after treatment with botanically derived 5AR inhibitors, suggesting these compounds may be effective, though larger trials are needed.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

This review discusses common hair loss conditions and explores how advancements in hair follicle biology might lead to more effective treatments but reports no new results.

research Management of Male Pattern Hair Loss

3 citations , July 2001 in “PubMed”

This article reviews various treatment options for androgenetic alopecia, like finasteride, camouflage agents, and surgical methods, emphasizing patient education about each approach's limitations, but reports no new clinical results.

research The Genetics of Androgenetic Alopecia

50 citations , March 2001 in “Clinics in Dermatology”

Genes and hormones cause hair loss, with four genes contributing equally.

research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)

89 citations , January 2001 in “Dermatologic Surgery”

Hair loss in women is common, starts in late 20s, and affects 30% of women over 50.

research Female Androgenetic Alopecia: A Separate Entity

50 citations , July 2000 in “Dermatologic Surgery”

Female and male AGA are different diseases.

research The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia

65 citations , October 1999 in “Journal of The American Academy of Dermatology”

In this study, finasteride doses as low as 0.2 mg per day significantly reduced both scalp skin and serum DHT levels in men with androgenetic alopecia.

research Clinical Dose Ranging Studies with Finasteride, a Type 2 5α-Reductase Inhibitor, in Men with Male Pattern Hair Loss

46 citations , October 1999 in “Journal of The American Academy of Dermatology”

This study found that finasteride at 1 mg/day was the most effective dose for treating male pattern hair loss, with similar efficacy to 5 mg/day and better results than lower doses.

research The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature

180 citations , September 1999 in “British Journal of Dermatology”

This review discusses the psychological and social impacts of androgenetic alopecia and suggests that medical treatments can have some positive psychological effects, highlighting the condition's moderate stress and impact on body image.

research Serum Androgens and Genetic Linkage Analysis in Early Onset Androgenetic Alopecia

32 citations , August 1999 in “Journal of Investigative Dermatology”

This study found that individuals with early onset extensive androgenetic alopecia have an elevated ratio of DHT to testosterone, but no significant genetic linkage to markers on chromosomes 2 or 5 was detected.

research Fortnightly Review: Male Pattern Androgenetic Alopecia

179 citations , September 1998 in “BMJ”

This article reviews the pathogenesis, genetic basis, and recent treatment breakthroughs for androgenetic alopecia but reports no new clinical findings.

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.

research Association of Benign Prostatic Hyperplasia with Male Pattern Baldness

54 citations , May 1998 in “Urology”

This study demonstrates that patients with benign prostatic hyperplasia have a higher severity and frequency of male pattern baldness compared to a control group.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

research The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients with Male Pattern Baldness

59 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.

research Natural Progression of Male Pattern Baldness in Young Men

71 citations , May 1991 in “Clinical and Experimental Dermatology”

Young men with male pattern baldness lose hair density over time without treatment.

research Alopecia: Histologic Changes

3 citations , January 1989 in “PubMed”

This paper discusses various histologic features to distinguish types of alopecia and reports no new clinical findings.

research Topical Minoxidil in Male Pattern Baldness: Effects of Discontinuation of Treatment

57 citations , July 1987 in “Journal of The American Academy of Dermatology”

In this study, minoxidil treatment was associated with an increase in nonvellus scalp hairs, but this effect was not sustained once the treatment was stopped.

research Use of Topical Minoxidil in the Treatment of Male Pattern Baldness

53 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil effectively regrows hair in male pattern baldness.

research The Inheritance Of Common Baldness: To Be Or Not To Be?

203 citations , November 1984 in “Journal of the American Academy of Dermatology”

This study presents evidence suggesting that androgenetic alopecia is most likely inherited through a polygenic model, challenging the traditional view that it is caused by a simple Mendelian autosomal dominant gene.

research Alopecia: A Pathologist's View

23 citations , July 1982 in “International Journal of Dermatology”

The review concludes that accurate diagnosis of different types of hair loss requires proper biopsy techniques and understanding the hair growth cycle and underlying causes.

research Minoxidil for Severe Hypertension After Failure of Other Hypotensive Drugs

86 citations , September 1977 in “BMJ”

Minoxidil effectively controls blood pressure in severe cases, but has serious side effects and causes hair growth in women.

research Pathologic Dynamics of Human Hair Loss

33 citations , September 1961 in “Archives of Dermatology”

This letter clarifies that colchicine induces anagen hair loss, as shown in animal studies, and corrects a misquotation by Kligman, who suggested it caused telogen effluvium.