CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia

April 2017 in “ Experimental dermatology ”

Ji‐Hyun Bae, Wu Jeong Hwang, Yongwoo Jang, Y. Lee, Da‐Eun Jang, J.H. Kim, Su Cheong Yeom

autoimmune-like alopecia CD80CD86 deficiency CD4+FoxP3+ regulatory T cells Tregs CD4+ T-cell infiltration CD8+ T-cell infiltration hair follicle destruction alopecia areata ALA regulatory T cells T-cell infiltration hair loss autoimmune alopecia

Studysummary This study found that B6.CD80CD86−/− mice developed autoimmune-like alopecia with nearly 100% incidence by 40 weeks, making them a promising model for studying human alopecia areata.

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research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies

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research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

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research Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata

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research Histopathology of Alopecia Areata, Acute and Chronic: Why Is It Important to the Clinician?

43 citations , May 2011 in “Dermatologic Therapy”

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research Primary Follicular Dystrophy With Scarring Dermatitis in C57BL/6 Mouse Substrains Resembles Central Centrifugal Cicatricial Alopecia in Humans

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research Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

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research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata

286 citations , August 2007 in “Journal of Clinical Investigation”

This review examines the interplay of genetics and neuroimmunology in alopecia areata, highlighting its potential to inform broader autoimmunity research, but reports no new findings.

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

77 citations , June 2002 in “Journal of Investigative Dermatology”

CD44 variant changes start alopecia areata, but don't maintain it.

research Alopecia Areata in Aging C3H/HeJ Mice

178 citations , June 1994 in “Journal of Investigative Dermatology”

This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.