Hair Growth Promotion by Necrostatin-1s

October 2020 in “ Scientific Reports ”

Mei Zheng, Nahyun Choi, YaeJi Jang, Da Eun Kwak, Young Soo Kim, Won-Serk Kim, Sang Ho Oh, Jong-Hyuk Sung

Necrostatin-1s RIPK1 inhibitor outer-root sheath cells ORS cells hair follicle telogen phase anagen phase Wnt/β-catenin signaling pathway Wnt3a Wnt5b necroptosis RIPK3

Studysummary In this study, Nec-1s was found to promote hair growth and may target necroptosis and the Wnt/β-catenin pathway for potential treatment of hair loss.

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This study found that Wnt signalling agonists increase and antagonists decrease in human scalp follicles from telogen to early-anagen, with differences from the mouse model suggesting targeted interventions for hair growth disorders.

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