Wnt-10b Secreted From Lymphocytes Promotes Differentiation of Skin Epithelial Cells

February 2006 in “ Biochemical and Biophysical Research Communications ”

Yukiteru Ouji, Masahide Yoshikawa, Akira Shiroi, Shigeaki Ishizaka

Wnt-10b lymphocytes skin epithelial cells hair follicle development mRNA Con A-stimulated lymphocytes mouse embryonic stem cells epithelial differentiation hair shaft growth canonical pathway immature epithelial cells hair shaft lineages IRS lineages

Studysummary Wnt-10b helps skin cells and hair grow.

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research Wnt-10b Promotes Differentiation of Skin Epithelial Cells In Vitro

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Wnt-10b helps skin cells develop into hair-related structures.

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This study describes the development of a new embryonic stem cell culture system that allows for the differentiation into mature hair follicle cells, potentially aiding research in hair follicle formation and regeneration.

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In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

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This article discusses the structure of hair follicles and their significance in evaluating hair disorders, but it does not report any new research findings.

research Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation

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Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

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This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.