Wnt-10b Secreted From Lymphocytes Promotes Differentiation of Skin Epithelial Cells

    February 2006 in “ Biochemical and Biophysical Research Communications ”
    Yukiteru Ouji, Masahide Yoshikawa, Akira Shiroi, Shigeaki Ishizaka
    TLDR Wnt-10b helps skin cells and hair grow.
    The study investigated the role of Wnt-10b, a protein secreted by activated lymphocytes, in the differentiation of skin epithelial cells and hair follicle development. It was found that Wnt-10b mRNA was expressed in Con A-stimulated lymphocytes and mouse embryonic stem cells, but not in unstimulated lymphocytes. The research highlighted the unique role of Wnt-10b in promoting epithelial differentiation and hair shaft growth, which was previously underexplored due to the unavailability of commercial Wnt-10b protein. The study used inbred female C3H/HeN mice and demonstrated that Wnt-10b activates the canonical pathway, enhancing the differentiation of immature epithelial cells into hair shaft and IRS lineages.
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