60 citations
,
September 2015 in “Expert Review of Clinical Immunology”
This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.
This study found that the interaction between heat shock protein 90 and lamin A/C is crucial for the growth, migration, and self-aggregation of dermal papilla cells, suggesting a potential role in alopecia areata mechanisms.
19 citations
,
March 2003 in “Journal of Investigative Dermatology”
This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.
17 citations
,
January 1985 in “International Journal of Dermatology”
In this study, minoxidil was found to suppress the activity of normal human T-lymphocytes in vitro, though the physiological relevance of this effect remains uncertain.
Dutasteride is preferred for addressing hair thinning as it targets DHT, the root cause, while oral minoxidil stimulates growth but doesn't address the cause. Users suggest dutasteride alone if minoxidil causes side effects, with a standard dose of 0.5mg being effective over time.