Mechanotransduction Unifies Healthy Non-Diabetic Wound Healing Over Time by Promoting a Cd14+/C1qa+ Fibroblast Subpopulation

    Katharina S. Berryman, Abdelrahman M. Alsharif, Mansi Singh … Kellen Chen
    Studysummary This research observed that diabetes impairs wound healing in mice by disrupting key mechanotransduction pathways in fibroblasts, which are crucial for the healing process. The study also suggests transcriptomic changes could inform future diabetic wound repair therapies.
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    Research cited in this study 4

    1. Targeting Wnt/β-Catenin Signaling and Its Interplay with TGF-β and Notch Signaling Pathways for the Treatment of Chronic Wounds Cell Communication and Signaling · 2024
    2. Fibroblast Heterogeneity in Healthy and Wounded Skin Cold Spring Harbor Perspectives in Biology · 2022
    3. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007