Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

    October 1999 in “ Journal of Clinical Investigation ”
    Noboru Sato, Philip L. Leopold, Ronald G. Crystal
    Studysummary This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.
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    Research cited in this study 7

    1. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    2. Characterization and Chromosomal Localization of Human Hair-Specific Keratin Genes and Comparative Expression During the Hair Growth Cycle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    3. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997
    4. Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy Molecular Medicine Today · 1996
    5. Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles Developmental Biology · 1993
    6. The Secret Life of the Hair Follicle Trends in genetics · 1992
    7. Growth of the Hair Physiological Reviews · 1954

    Related research 4

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    2. Hedgehog Signaling in Skin Development and Cancer Experimental Dermatology · 2006
    3. Suppression of Hair Follicle Development Inhibits Induction of Sonic Hedgehog, Patched, and Patched-2 in Hair Germs in Mice Archives of Dermatological Research · 2001
    4. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999