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research Genetically Induced Cell Death in Bulge Stem Cells Reveals Their Redundancy for Hair and Epidermal Regeneration

13 citations , December 2014 in “Stem Cells”

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

research IL-1 Receptor–Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response after Exposure to UVB Radiation

20 citations , July 2017 in “Journal of Investigative Dermatology”

IL-1 receptor absence in mice leads to skin cysts and changes in immune response after UVB exposure.

research ELL Facilitates RNA Polymerase II–Mediated Transcription of Human Epidermal Proliferation Genes

4 citations , May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that ELL is crucial for maintaining the proliferative capacity of the basal layer in human epidermal keratinocytes by stabilizing RNA polymerase II at the transcription start site.

research Cell death as an architect of adult skin stem cell niches

April 2024 in “Cell death and differentiation”

This study discusses how different modes of regulated cell death in keratinocytes affect skin stem cell niches, and their role in skin inflammation, injury repair, and cancer, based on findings from human dermatological conditions and experimental mouse models.

research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study reported that in mouse models, deletion of EGFR resulted in stem cell hyper-proliferation followed by apoptosis, leading to scarring alopecia, and implicated EGFR's role in maintaining hair follicle quiescence and immune privilege during inflammation.

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community Best Microneedling Depth and Frequency?

in Microneedling 5 upvotes 2 years ago

The conversation is about the best microneedling depth and frequency for hair loss treatment. The user recommends 1.5mm once a week.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community Microneedling technique clarification

in Microneedling 16 upvotes 2 years ago

The conversation is about using a Dr. Pen for microneedling on a widow's peak, with advice to use a depth of 1.25mm and hold it in place for 10 seconds. The user is also using minoxidil.

community Why do I see so many people here recommend microneedling?

109 upvotes 3 years ago

The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

community People who don’t microneedle, why?

146 upvotes 11 months ago

Microneedling is often combined with minoxidil for hair growth, but concerns about scalp damage, pain, and effectiveness deter some users. Alternatives like finasteride, dutasteride, tretinoin, and laser treatments are preferred by others.

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learn Epidermal Growth Factor

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