Epithelial Cells in the Hair Follicle Bulge Do Not Contribute to Epidermal Regeneration After Glucocorticoid-Induced Cutaneous Atrophy

    July 2007 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Dmitry V. Chebotaev, Alexander Yemelyanov, Robert M. Lavker, Irina Budunova
    Studysummary This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
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    Research cited in this study 6

    1. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    2. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    3. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    4. Altered Skin Development and Impaired Proliferative and Inflammatory Responses in Transgenic Mice Overexpressing the Glucocorticoid Receptor The FASEB Journal · 2001
    5. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    6. Urokinase Is a Positive Regulator of Epidermal Proliferation In Vivo Journal of Investigative Dermatology · 1999