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research Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy

23 citations , July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.

research An overview of animal models induced by glucocorticoids

September 2023 in “Physiology and Pharmacology”

This review provides an overview of various animal models used to study glucocorticoid-induced humanlike disorders, highlighting their utility in understanding side effects across multiple body systems, such as hypertension, osteoporosis, and depression-like behavior.

research A novel actor in skin biology: the mineralocorticoid receptor

7 citations , October 2015 in “Experimental dermatology”

This study found that topical MR blockers alongside glucocorticoids may limit glucocorticoid-induced skin atrophy, suggesting MR's significant role in skin-related endocrinology.

research Stem Cells in the Hair Follicle and Interfollicular Epidermis of Mice following Topical Application of Fluocinolone Acetonide

2 citations , November 2007 in “Journal of Investigative Dermatology”

This study found that bulge keratinocytes in mice develop resistance to glucocorticoid treatment more slowly than interfollicular keratinocytes and do not significantly aid in repairing glucocorticoid-induced skin atrophy within five days.

research Glucocorticoids Influencing Wnt/β-Catenin Pathway; Multiple Sites, Heterogeneous Effects

37 citations , March 2020 in “Molecules”

This review outlines the adverse effects of glucocorticoid excess on bones, adipose tissue, brain, and skin, with a focus on the Wnt/β-catenin pathway, and reports no new research findings.

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Community Join

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community DHT is NOT very important for adults, is it?

124 upvotes 5 months ago

A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Got prescribed clobetasol propionate 0.05%

5 upvotes 2 weeks ago

The user is experiencing diffuse thinning and receded hairline, using dutasteride, minoxidil, and ketoconazole without regrowth, and was prescribed clobetasol propionate 0.05% with salicylic acid for possible inflammation. Other users caution against using the strong steroid without a serious condition, sharing experiences of adverse effects and alternative treatments for scalp issues.

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Learn

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learn Hydrocortisone

Mild corticosteroid used on the skin and scalp

What are the risks of long-term hydrocortisone use on the scalp? Dermatology reviews describe long-term topical corticosteroid use as causing skin thinning, delayed healing, greater infection risk, possible suppression of the body's own cortisol, and rebound flares on stopping. US over-the-counter hydrocortisone labels say to stop and ask a doctor if symptoms last more than seven days.

learn Hydrocortisone Butyrate

learn hydrocortisone acetate IP

learn Baricitinib

JAK inhibitor pill used for severe alopecia areata

learn HYDROXYPROPYLGLUCONAMIDE

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Clinics

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Experts

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SMP Specialist
Noelle Skin
Nice, France

Noelle Skin