Ultrastructural Localization of Hair Keratins, High Sulfur Keratin-Associated Proteins and Sulfhydryl Oxidase in Human Hair

    February 2016 in “ Anatomical Science International ”
    Lorenzo Alibardi
    TLDR Hair proteins change location and structure as hair cells mature.
    The study investigated the ultrastructural localization of hair keratins, high-sulfur keratin-associated proteins (KAPs), and sulfhydryl oxidase in the human hair using transmission electron microscopy. It confirmed previous findings on keratin distribution and revealed that sulfur-rich KAP1 was primarily found in the cortex but disappeared in fully cornified cells, while K26 was localized in the exocuticle and endocuticle. Sulfhydryl oxidase was sparsely present in differentiating cortical cells and weakly in cuticle cells, but absent in the medulla and inner root sheath. The study suggested that these proteins are initially produced in the cytoplasm among keratin bundles but undergo changes during cornification, altering the epitopes recognized by antibodies.
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