This paper has been retracted. The journal has withdrawn it. Retracted work should not be relied on. The summary below describes what the paper claimed, not a finding that still stands.

Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study

September 2024 in “ Skin Research and Technology ”

Yue Zhao, Furong Guo, M. Guo

alopecia areata thyroid dysfunction hypothyroidism Hashimoto's thyroiditis subacute thyroiditis Mendelian randomization AA

Studysummary The study initially suggested a genetic link between thyroid issues and hair loss.

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Research cited in this study

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research Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

3 citations , July 2024 in “Skin Research and Technology”

Asthma may increase the risk of alopecia areata.

research Retracted: Causal Role of Immune Cells in Alopecia Areata: A Two-Sample Mendelian Randomization Study

14 citations , January 2024 in “Skin Research and Technology”

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

research Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

2 citations , October 2023 in “Dermatology and therapy”

This study conducted in Europe found that both physicians and patients generally agreed on the severity of alopecia areata, with higher physician-rated severity linked to increased patient-reported burdens such as anxiety, depression, and work impairment.

research Impact of Thyroid Dysfunction on Hair Disorders

August 2023 in “Cureus”

This study reviewed existing literature to demonstrate that thyroid disorders have a significant and underestimated impact on hair loss, highlighting gaps in current knowledge and the need for further research to better diagnose and manage hair disorders linked to thyroid dysfunction.

research Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

3 citations , July 2023 in “International journal of molecular sciences”

This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

75 citations , March 2023 in “JAMA Dermatology”

This study reported that the prevalence of alopecia areata in the US slightly increased from 0.199% to 0.222% between 2016 and 2019, with higher rates observed in women and adults.

research Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs

1 citations , March 2023 in “Clinical, Cosmetic and Investigational Dermatology”

This review discusses recent advances in understanding and treating alopecia areata, emphasizing the ongoing challenges and unmet needs in disease management; it reports no new clinical findings.

research An Update on Alopecia and Its Association With Thyroid Autoimmune Diseases

January 2023 in “European endocrinology”

This review explores the association between alopecia and thyroid autoimmune disease, also highlighting a linked increased risk of thyroid cancer, but presents no new clinical findings.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

This background review discusses alopecia areata, highlighting the role of CD8+NKG2D+ T cells in hair follicle pathogenesis, and notes that the exact mechanisms causing hair loss remain unclear.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum

22 citations , June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

research Genetic Basis of Alopecia Areata

40 citations , October 2012 in “Dermatologic clinics”

This review highlights the need for a deeper understanding of the genetic mechanisms in alopecia areata to develop evidence-based treatments, but it provides no new experimental results.

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

109 citations , May 2011 in “Dermatologic Therapy”

This article reviews the characteristics, associations, and diagnostic criteria for alopecia areata and reports no new clinical findings; the authors note the disease's unpredictable course and variable prognosis.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.