Thiosulfate promotes hair growth in mouse model

    Motoko Maekawa, Tetsuo Ohnishi, Shabeesh Balan, Yu Hisano, Yayoi Nozaki, Hideki Ohba, Manabu Toyoshima, Chie Shimamoto, Chinatsu Tabata, Yuina Wada, Takeo Yoshikawa
    Image of study
    TLDR Thiosulfate may help hair grow faster in mice and works well with a common hair growth treatment.
    In a 2018 study, sodium thiosulfate (STS) was found to promote hair growth in mice by stimulating resting hair follicles to reenter the growth phase and enhancing the effects of minoxidil (MXD), a common hair growth treatment. The study used two mouse models to test the effects of STS on both resting and active hair follicles, with sample sizes ranging from 5 to 12 mice per treatment group. STS, especially at a 10% concentration, was shown to increase hair growth speed and, when combined with 1% MXD, had a significant additive effect on hair growth. The study suggested that the hair growth-promoting activity of STS might be due to vasorelaxation and the generation of hydrogen sulfide (H₂S), which has vasorelaxation and anti-inflammatory/anti-oxidative properties. No adverse systemic health effects were observed, and the study concluded that STS has the potential to be a novel treatment for hair loss, working synergistically with MXD. Further research and clinical trials are needed to understand the precise mechanisms by which STS promotes hair growth.
    View this study on →

    Cited in this study