Efficacy of Thermus Thermophilus Fermentation Extract in Promoting Hair Growth and Improving Scalp Health in Androgenic Alopecia: A Clinical and In Vitro Study
March 2025
in “
Journal of Cosmetic Dermatology
”
Thermus thermophilus fermentation extract androgenic alopecia hair density scalp health hair thickness scalp barrier function trans-epidermal water loss sebum production hair follicle proliferation hair shafts anti-inflammatory effects reactive oxygen species pro-inflammatory cytokines Wnt signaling pathway TGF-β signaling pathway TTFE AGA
TLDR Thermus thermophilus extract improves hair growth and scalp health in men with hair loss.
The study assessed the effects of Thermus thermophilus fermentation extract (TTFE) on 32 male subjects with androgenic alopecia (AGA) over 12 weeks, showing significant improvements in hair density, appearance, and scalp health. TTFE reduced hair loss areas, increased hair thickness, and improved scalp barrier function by decreasing trans-epidermal water loss and sebum production. It also promoted hair follicle proliferation, strengthened hair shafts, and exhibited anti-inflammatory effects by reducing reactive oxygen species and pro-inflammatory cytokines. TTFE modulated Wnt and TGF-β signaling pathways, promoting hair growth. Despite promising results, further research is needed due to the study's small sample size and limited population diversity.
